STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death

STING gain-of-function mutations cause lung disease and T cell cytopenia through unknown mechanisms. Here, we found that these mutants induce chronic activation of ER stress and unfolded protein response (UPR), leading to T cell death by apoptosis in the Sting(N153S/+) mouse and in human T cells. Me...

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Detalles Bibliográficos
Autores principales: Wu, Jianjun, Chen, Yu-Ju, Dobbs, Nicole, Sakai, Tomomi, Liou, Jen, Miner, Jonathan J., Yan, Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446864/
https://www.ncbi.nlm.nih.gov/pubmed/30886058
http://dx.doi.org/10.1084/jem.20182192

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