KAT8 selectively inhibits antiviral immunity by acetylating IRF3

The transcription factor interferon regulatory factor 3 (IRF3) is essential for virus infection–triggered induction of type I interferons (IFN-I) and innate immune responses. IRF3 activity is tightly regulated by conventional posttranslational modifications (PTMs) such as phosphorylation and ubiquit...

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Detalles Bibliográficos
Autores principales: Huai, Wanwan, Liu, Xingguang, Wang, Chunmei, Zhang, Yunkai, Chen, Xi, Chen, Xiang, Xu, Sheng, Thomas, Tim, Li, Nan, Cao, Xuetao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446880/
https://www.ncbi.nlm.nih.gov/pubmed/30842237
http://dx.doi.org/10.1084/jem.20181773

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446880/
https://www.ncbi.nlm.nih.gov/pubmed/30842237
http://dx.doi.org/10.1084/jem.20181773

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