Advances in mRNA Vaccines for Infectious Diseases

During the last two decades, there has been broad interest in RNA-based technologies for the development of prophylactic and therapeutic vaccines. Preclinical and clinical trials have shown that mRNA vaccines provide a safe and long-lasting immune response in animal models and humans. In this review...

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Detalles Bibliográficos
Autores principales: Zhang, Cuiling, Maruggi, Giulietta, Shan, Hu, Li, Junwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446947/
https://www.ncbi.nlm.nih.gov/pubmed/30972078
http://dx.doi.org/10.3389/fimmu.2019.00594
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author Zhang, Cuiling
Maruggi, Giulietta
Shan, Hu
Li, Junwei
author_facet Zhang, Cuiling
Maruggi, Giulietta
Shan, Hu
Li, Junwei
author_sort Zhang, Cuiling
collection PubMed
description During the last two decades, there has been broad interest in RNA-based technologies for the development of prophylactic and therapeutic vaccines. Preclinical and clinical trials have shown that mRNA vaccines provide a safe and long-lasting immune response in animal models and humans. In this review, we summarize current research progress on mRNA vaccines, which have the potential to be quick-manufactured and to become powerful tools against infectious disease and we highlight the bright future of their design and applications.
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spelling pubmed-64469472019-04-10 Advances in mRNA Vaccines for Infectious Diseases Zhang, Cuiling Maruggi, Giulietta Shan, Hu Li, Junwei Front Immunol Immunology During the last two decades, there has been broad interest in RNA-based technologies for the development of prophylactic and therapeutic vaccines. Preclinical and clinical trials have shown that mRNA vaccines provide a safe and long-lasting immune response in animal models and humans. In this review, we summarize current research progress on mRNA vaccines, which have the potential to be quick-manufactured and to become powerful tools against infectious disease and we highlight the bright future of their design and applications. Frontiers Media S.A. 2019-03-27 /pmc/articles/PMC6446947/ /pubmed/30972078 http://dx.doi.org/10.3389/fimmu.2019.00594 Text en Copyright © 2019 Zhang, Maruggi, Shan and Li. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhang, Cuiling
Maruggi, Giulietta
Shan, Hu
Li, Junwei
Advances in mRNA Vaccines for Infectious Diseases
title Advances in mRNA Vaccines for Infectious Diseases
title_full Advances in mRNA Vaccines for Infectious Diseases
title_fullStr Advances in mRNA Vaccines for Infectious Diseases
title_full_unstemmed Advances in mRNA Vaccines for Infectious Diseases
title_short Advances in mRNA Vaccines for Infectious Diseases
title_sort advances in mrna vaccines for infectious diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446947/
https://www.ncbi.nlm.nih.gov/pubmed/30972078
http://dx.doi.org/10.3389/fimmu.2019.00594
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AT maruggigiulietta advancesinmrnavaccinesforinfectiousdiseases
AT shanhu advancesinmrnavaccinesforinfectiousdiseases
AT lijunwei advancesinmrnavaccinesforinfectiousdiseases

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