Tumor necrosis factor α knockout impaired tumorigenesis in chronic myeloid leukemia cells partly by metabolism modification and miRNA regulation

PURPOSE: Half of the chronic myeloid leukemia (CML) patients with sustained deep molecular response suffer from relapse after discontinuation mainly because tyrosine kinase inhibitors (TKIs) cannot eradicate leukemia stem cells (LSCs). In addition, tumor necrosis factor α (TNF-α) is highly detected...

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Detalles Bibliográficos
Autores principales: Shen, Na, Liu, Songya, Cui, Jieke, Li, Qing, You, Yong, Zhong, Zhaodong, Cheng, Fanjun, Guo, An-Yuan, Zou, Ping, Yuan, Guolin, Zhu, Xiaojian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446984/
https://www.ncbi.nlm.nih.gov/pubmed/31015764
http://dx.doi.org/10.2147/OTT.S197535

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