Bidirectional Modulation of HIF-2 Activity through Chemical Ligands

Hypoxia-inducible factor-2 (HIF-2) is a heterodimeric transcription factor formed through dimerization between an oxygen-sensitive subunit HIF-2α subunit and its obligate partner subunit ARNT. Enhanced HIF-2 activity drives some cancers, while reduced activity causes anemia in chronic kidney disease...

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Detalles Bibliográficos
Autores principales: Wu, Dalei, Su, Xiaoyu, Lu, Jingping, Li, Sheng, Hood, Becky L., Vasile, Stefan, Potluri, Nalini, Diao, Xiaotong, Kim, Youngchang, Khorasanizadeh, Sepideh, Rastinejad, Fraydoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447045/
https://www.ncbi.nlm.nih.gov/pubmed/30804532
http://dx.doi.org/10.1038/s41589-019-0234-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447045/
https://www.ncbi.nlm.nih.gov/pubmed/30804532
http://dx.doi.org/10.1038/s41589-019-0234-5

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