Cargando…

A novel quantitative approach for measuring the reservoir of latent HIV-1 proviruses

A stable latent reservoir for HIV-1 in resting CD4(+) T-cells precludes cure(1–3). Curative strategies targeting the reservoir are being tested(4,5) and require accurate, scalable reservoir assays. The reservoir was defined with quantitative viral outgrowth assays (QVOAs) for cells releasing infecti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bruner, Katherine M., Wang, Zheng, Simonetti, Francesco R., Bender, Alexandra M., Kwon, Kyungyoon J., Sengupta, Srona, Fray, Emily J., Beg, Subul A., Antar, Annukka A. R., Jenike, Katharine M., Bertagnolli, Lynn N., Capoferri, Adam A., Kufera, Joshua T., Timmons, Andrew, Nobles, Christopher, Gregg, John, Wada, Nikolas, Ho, Ya-Chi, Zhang, Hao, Margolick, Joseph B., Blankson, Joel N., Deeks, Steven G., Bushman, Frederic D., Siliciano, Janet D., Laird, Gregory M., Siliciano, Robert F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447073/ https://www.ncbi.nlm.nih.gov/pubmed/30700913 http://dx.doi.org/10.1038/s41586-019-0898-8

Ejemplares similares

Proliferation of latently infected CD4(+) T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics
por: Hosmane, Nina N., et al.
Publicado: (2017)

Measuring the latent reservoir for HIV-1: Quantification bias in near full-length genome sequencing methods
por: White, Jennifer A., et al.
Publicado: (2022)

Defective proviruses rapidly accumulate during acute HIV-1 infection
por: Bruner, Katherine M., et al.
Publicado: (2016)

Complex decay dynamics of HIV virions, intact and defective proviruses, and 2LTR circles following initiation of antiretroviral therapy
por: White, Jennifer A., et al.
Publicado: (2022)

Last in first out: SIV proviruses seeded later in infection are harbored in short-lived CD4(+) T cells
por: Sambaturu, Narmada, et al.
Publicado: (2023)

Clonally expanded HIV-1 proviruses with 5′-leader defects can give rise to nonsuppressible residual viremia
por: White, Jennifer A., et al.
Publicado: (2023)

Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells
por: Hansen, Erik C, et al.
Publicado: (2016)

HIV Prevention and Treatment Fields Join Forces
por: Deeks, Steven G., et al.
Publicado: (2014)

A cell-free antigen processing system informs HIV-1 epitope selection and vaccine design
por: Sengupta, Srona, et al.
Publicado: (2023)

Primary CD8(+) T cells from elite suppressors effectively eliminate non-productively HIV-1 infected resting and activated CD4(+) T cells
por: Buckheit, Robert W, et al.
Publicado: (2013)

Rapid Quantification of the Latent Reservoir for HIV-1 Using a Viral Outgrowth Assay
por: Laird, Gregory M., et al.
Publicado: (2013)

Maintenance of viral suppression in HIV-1–infected HLA-B*57(+) elite suppressors despite CTL escape mutations
por: Bailey, Justin R., et al.
Publicado: (2006)

Viral suppression of multiple escape mutants by de novo CD8(+ )T cell responses in a human immunodeficiency virus-1 Infected elite suppressor
por: O'Connell, Karen A, et al.
Publicado: (2011)

CD8(+) T cells from HLA-B*57 elite suppressors effectively suppress replication of HIV-1 escape mutants
por: Pohlmeyer, Christopher W, et al.
Publicado: (2013)

Biphasic decay of intact SHIV genomes following initiation of antiretroviral therapy complicates analysis of interventions targeting the reservoir
por: Kumar, Mithra R., et al.
Publicado: (2023)

Evaluating Clonal Expansion of HIV-Infected Cells: Optimization of PCR Strategies to Predict Clonality
por: Laskey, Sarah B., et al.
Publicado: (2016)

TCR-mimic bispecific antibodies to target the HIV-1 reservoir
por: Sengupta, Srona, et al.
Publicado: (2022)

HIV Infected T Cells Can Proliferate in vivo Without Inducing Expression of the Integrated Provirus
por: Musick, Andrew, et al.
Publicado: (2019)

Measuring replication competent HIV-1: advances and challenges in defining the latent reservoir
por: Wang, Zheng, et al.
Publicado: (2018)

Impact of misclassified defective proviruses on HIV reservoir measurements
por: Reeves, Daniel B., et al.
Publicado: (2023)

Novel ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo
por: Bullen, C. Korin, et al.
Publicado: (2014)

The host genomic environment of the provirus determines the abundance of HTLV-1–infected T-cell clones
por: Gillet, Nicolas A., et al.
Publicado: (2011)

HIV replication and evolution in patients on highly active antiretroviral therapy
por: Siliciano, Robert F
Publicado: (2006)

Novel structurally related compounds reactivate latent HIV-1 in a bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation
por: Xing, Sifei, et al.
Publicado: (2012)

Challenges in Quantifying Cytosine Methylation in the HIV Provirus
por: LaMere, Sarah A., et al.
Publicado: (2019)

Prolonged control of replication-competent dual- tropic human immunodeficiency virus-1 following cessation of highly active antiretroviral therapy
por: Salgado, Maria, et al.
Publicado: (2011)

Insufficient Evidence for Rare Activation of Latent HIV in the Absence of Reservoir-Reducing Interventions
por: Hill, Alison L., et al.
Publicado: (2016)

Assessing the Suitability of Next-Generation Viral Outgrowth Assays to Measure Human Immunodeficiency Virus 1 Latent Reservoir Size
por: Stone, Mars, et al.
Publicado: (2020)

Designing and Interpreting Limiting Dilution Assays: General Principles and Applications to the Latent Reservoir for Human Immunodeficiency Virus-1
por: Rosenbloom, Daniel I. S., et al.
Publicado: (2015)

CD4(+) and CD8(+) T Cell Activation Are Associated with HIV DNA in Resting CD4(+) T Cells
por: Cockerham, Leslie R., et al.
Publicado: (2014)

Cellular Activation, Differentiation, and Proliferation Influence the Dynamics of Genetically Intact Proviruses Over Time
por: Horsburgh, Bethany A, et al.
Publicado: (2021)

Mycobacterium tuberculosis Complex Enhances Susceptibility of CD4 T Cells to HIV through a TLR2-Mediated Pathway
por: Thayil, Seema M., et al.
Publicado: (2012)

Characterization, mapping and distribution of the two XMRV parental proviruses
por: Cingöz, Oya, et al.
Publicado: (2011)

Limits on Replenishment of the Resting CD4(+) T Cell Reservoir for HIV in Patients on HAART
por: Sedaghat, Ahmad R, et al.
Publicado: (2007)

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations
por: Deng, Kai, et al.
Publicado: (2015)

Evolution of the HIV-1 nef gene in HLA-B*57 Positive Elite Suppressors
por: Salgado, Maria, et al.
Publicado: (2010)

The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy
por: McMyn, Natalie F., et al.
Publicado: (2023)

Multiple genetic programs contribute to CD4 T cell memory differentiation and longevity by maintaining T cell quiescence
por: Song, Nianbin, et al.
Publicado: (2020)

Targeting of HIV-1 Antigens for Rapid Intracellular Degradation Enhances Cytotoxic T Lymphocyte (CTL) Recognition and the Induction of De Novo CTL Responses In Vivo After Immunization
por: Tobery, Timothy W., et al.
Publicado: (1997)

Efforts to eliminate the latent reservoir in resting CD4+ T cells: strategies for curing HIV-1 infection
por: Ho, Ya-Chi, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_q3tl9egc752q4vvct4ivdpl9p9