Rational design and in vivo selection of SHIVs encoding transmitted/founder subtype C HIV-1 envelopes

Chimeric Simian-Human Immunodeficiency Viruses (SHIVs) are an important tool for evaluating anti-HIV Env interventions in nonhuman primate (NHP) models. However, most unadapted SHIVs do not replicate well in vivo limiting their utility. Furthermore, adaptation in vivo often negatively impacts fundam...

Descripción completa

Detalles Bibliográficos
Autores principales: O’Brien, Sean P., Swanstrom, Adrienne E., Pegu, Amarendra, Ko, Sung-Youl, Immonen, Taina T., Del Prete, Gregory Q., Fennessey, Christine M., Gorman, Jason, Foulds, Kathryn E., Schmidt, Stephen D., Doria-Rose, Nicole, Williamson, Carolyn, Hatziioannou, Theodora, Bieniasz, Paul D., Li, Hui, Shaw, George M., Mascola, John R., Koup, Richard A., Kwong, Peter D., Lifson, Jeffrey D., Roederer, Mario, Keele, Brandon F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447185/
https://www.ncbi.nlm.nih.gov/pubmed/30943274
http://dx.doi.org/10.1371/journal.ppat.1007632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447185/
https://www.ncbi.nlm.nih.gov/pubmed/30943274
http://dx.doi.org/10.1371/journal.ppat.1007632

Ejemplares similares