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Rational design and in vivo selection of SHIVs encoding transmitted/founder subtype C HIV-1 envelopes

Chimeric Simian-Human Immunodeficiency Viruses (SHIVs) are an important tool for evaluating anti-HIV Env interventions in nonhuman primate (NHP) models. However, most unadapted SHIVs do not replicate well in vivo limiting their utility. Furthermore, adaptation in vivo often negatively impacts fundam...

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Detalles Bibliográficos
Autores principales:	O’Brien, Sean P., Swanstrom, Adrienne E., Pegu, Amarendra, Ko, Sung-Youl, Immonen, Taina T., Del Prete, Gregory Q., Fennessey, Christine M., Gorman, Jason, Foulds, Kathryn E., Schmidt, Stephen D., Doria-Rose, Nicole, Williamson, Carolyn, Hatziioannou, Theodora, Bieniasz, Paul D., Li, Hui, Shaw, George M., Mascola, John R., Koup, Richard A., Kwong, Peter D., Lifson, Jeffrey D., Roederer, Mario, Keele, Brandon F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447185/ https://www.ncbi.nlm.nih.gov/pubmed/30943274 http://dx.doi.org/10.1371/journal.ppat.1007632

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