The relationship between thyroid function and cerebral blood flow in mild cognitive impairment and Alzheimer’s disease

The thyroid hormones have been reported to be associated with cognitive decline and Alzheimer’s disease. The relationship between thyroid function within the normal range and cerebral blood flow in Alzheimer’s disease patients has been shown in a recent study. Mild cognitive impairment is often the...

Descripción completa

Detalles Bibliográficos
Autores principales: Nomoto, Shohei, Kinno, Ryuta, Ochiai, Hirotaka, Kubota, Satomi, Mori, Yukiko, Futamura, Akinori, Sugimoto, Azusa, Kuroda, Takeshi, Yano, Satoshi, Murakami, Hidetomo, Shirasawa, Takako, Yoshimoto, Takahiko, Minoura, Akira, Kokaze, Akatsuki, Ono, Kenjiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447192/
https://www.ncbi.nlm.nih.gov/pubmed/30943231
http://dx.doi.org/10.1371/journal.pone.0214676
_version_ 1783408473743032320
author Nomoto, Shohei
Kinno, Ryuta
Ochiai, Hirotaka
Kubota, Satomi
Mori, Yukiko
Futamura, Akinori
Sugimoto, Azusa
Kuroda, Takeshi
Yano, Satoshi
Murakami, Hidetomo
Shirasawa, Takako
Yoshimoto, Takahiko
Minoura, Akira
Kokaze, Akatsuki
Ono, Kenjiro
author_facet Nomoto, Shohei
Kinno, Ryuta
Ochiai, Hirotaka
Kubota, Satomi
Mori, Yukiko
Futamura, Akinori
Sugimoto, Azusa
Kuroda, Takeshi
Yano, Satoshi
Murakami, Hidetomo
Shirasawa, Takako
Yoshimoto, Takahiko
Minoura, Akira
Kokaze, Akatsuki
Ono, Kenjiro
author_sort Nomoto, Shohei
collection PubMed
description The thyroid hormones have been reported to be associated with cognitive decline and Alzheimer’s disease. The relationship between thyroid function within the normal range and cerebral blood flow in Alzheimer’s disease patients has been shown in a recent study. Mild cognitive impairment is often the first stage of Alzheimer’s disease; thus, early diagnosis is important. The present study investigated the relationship between thyroid function and regional cerebral blood flow in patients with mild cognitive impairment and Alzheimer’s disease. A total of 122 memory clinic outpatients who underwent thyroid function testing and single photon emission computed tomography were divided into mild cognitive impairment, Alzheimer’s disease, and Normal groups. Regional cerebral blood flow was calculated using a three-dimensional stereotactic region of interest template in an automated cerebral perfusion single photon emission computed tomography analysis system. Multiple regression analysis adjusted for age and sex was conducted to examine the relationships between thyroid hormones and regional cerebral blood flow. Thyroid stimulating hormone was significantly associated with regional cerebral blood flow in the bilateral temporal, bilateral pericallosal, and bilateral hippocampal regions in the mild cognitive impairment group. In the Alzheimer’s disease group, free triiodothyronine was significantly associated with regional cerebral blood flow in the bilateral parietal, right temporal, and bilateral pericallosal regions. The present study showed the association of thyroid stimulating hormone with regional cerebral blood flow in the mild cognitive impairment group and the association of free triiodothyronine with regional cerebral blood flow in the Alzheimer’s disease group. These study findings could contribute to the early diagnosis of mild cognitive impairment at general memory clinics and the prevention of subsequent progression to Alzheimer’s disease.
format Online
Article
Text
id pubmed-6447192
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-64471922019-04-17 The relationship between thyroid function and cerebral blood flow in mild cognitive impairment and Alzheimer’s disease Nomoto, Shohei Kinno, Ryuta Ochiai, Hirotaka Kubota, Satomi Mori, Yukiko Futamura, Akinori Sugimoto, Azusa Kuroda, Takeshi Yano, Satoshi Murakami, Hidetomo Shirasawa, Takako Yoshimoto, Takahiko Minoura, Akira Kokaze, Akatsuki Ono, Kenjiro PLoS One Research Article The thyroid hormones have been reported to be associated with cognitive decline and Alzheimer’s disease. The relationship between thyroid function within the normal range and cerebral blood flow in Alzheimer’s disease patients has been shown in a recent study. Mild cognitive impairment is often the first stage of Alzheimer’s disease; thus, early diagnosis is important. The present study investigated the relationship between thyroid function and regional cerebral blood flow in patients with mild cognitive impairment and Alzheimer’s disease. A total of 122 memory clinic outpatients who underwent thyroid function testing and single photon emission computed tomography were divided into mild cognitive impairment, Alzheimer’s disease, and Normal groups. Regional cerebral blood flow was calculated using a three-dimensional stereotactic region of interest template in an automated cerebral perfusion single photon emission computed tomography analysis system. Multiple regression analysis adjusted for age and sex was conducted to examine the relationships between thyroid hormones and regional cerebral blood flow. Thyroid stimulating hormone was significantly associated with regional cerebral blood flow in the bilateral temporal, bilateral pericallosal, and bilateral hippocampal regions in the mild cognitive impairment group. In the Alzheimer’s disease group, free triiodothyronine was significantly associated with regional cerebral blood flow in the bilateral parietal, right temporal, and bilateral pericallosal regions. The present study showed the association of thyroid stimulating hormone with regional cerebral blood flow in the mild cognitive impairment group and the association of free triiodothyronine with regional cerebral blood flow in the Alzheimer’s disease group. These study findings could contribute to the early diagnosis of mild cognitive impairment at general memory clinics and the prevention of subsequent progression to Alzheimer’s disease. Public Library of Science 2019-04-03 /pmc/articles/PMC6447192/ /pubmed/30943231 http://dx.doi.org/10.1371/journal.pone.0214676 Text en © 2019 Nomoto et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Nomoto, Shohei
Kinno, Ryuta
Ochiai, Hirotaka
Kubota, Satomi
Mori, Yukiko
Futamura, Akinori
Sugimoto, Azusa
Kuroda, Takeshi
Yano, Satoshi
Murakami, Hidetomo
Shirasawa, Takako
Yoshimoto, Takahiko
Minoura, Akira
Kokaze, Akatsuki
Ono, Kenjiro
The relationship between thyroid function and cerebral blood flow in mild cognitive impairment and Alzheimer’s disease
title The relationship between thyroid function and cerebral blood flow in mild cognitive impairment and Alzheimer’s disease
title_full The relationship between thyroid function and cerebral blood flow in mild cognitive impairment and Alzheimer’s disease
title_fullStr The relationship between thyroid function and cerebral blood flow in mild cognitive impairment and Alzheimer’s disease
title_full_unstemmed The relationship between thyroid function and cerebral blood flow in mild cognitive impairment and Alzheimer’s disease
title_short The relationship between thyroid function and cerebral blood flow in mild cognitive impairment and Alzheimer’s disease
title_sort relationship between thyroid function and cerebral blood flow in mild cognitive impairment and alzheimer’s disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447192/
https://www.ncbi.nlm.nih.gov/pubmed/30943231
http://dx.doi.org/10.1371/journal.pone.0214676
work_keys_str_mv AT nomotoshohei therelationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease
AT kinnoryuta therelationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease
AT ochiaihirotaka therelationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease
AT kubotasatomi therelationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease
AT moriyukiko therelationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease
AT futamuraakinori therelationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease
AT sugimotoazusa therelationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease
AT kurodatakeshi therelationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease
AT yanosatoshi therelationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease
AT murakamihidetomo therelationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease
AT shirasawatakako therelationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease
AT yoshimototakahiko therelationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease
AT minouraakira therelationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease
AT kokazeakatsuki therelationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease
AT onokenjiro therelationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease
AT nomotoshohei relationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease
AT kinnoryuta relationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease
AT ochiaihirotaka relationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease
AT kubotasatomi relationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease
AT moriyukiko relationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease
AT futamuraakinori relationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease
AT sugimotoazusa relationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease
AT kurodatakeshi relationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease
AT yanosatoshi relationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease
AT murakamihidetomo relationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease
AT shirasawatakako relationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease
AT yoshimototakahiko relationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease
AT minouraakira relationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease
AT kokazeakatsuki relationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease
AT onokenjiro relationshipbetweenthyroidfunctionandcerebralbloodflowinmildcognitiveimpairmentandalzheimersdisease

Ejemplares similares