Angiolymphoid Hyperplasia with Eosinophilia Successfully Treated with Cryotherapy

BACKGROUND: Angiolymphoid hyperplasia with eosinophilia is an uncommon, benign, vasoproliferative cutaneous neoplasm with uncertain origin. It preferably affects middle-aged adults, manifesting as plum-colored pruritic papules, nodules and plaques, which can persist indefinitely, relapsing over time. Different response/resistance to various therapeutic modalities and frequent recurrences impose a great therapeutic dilemma. CASE PRESENTATION: Herein, we present a 77-year-old male patient with a 7-month-history of unrecognized cutaneous manifestations on his left shoulder and flank. Based on the investigations, the diagnosis of angiolymphoid hyperplasia with eosinophilia was established. We applied cryotherapy as a treatment of choice. The complete regression of the skin lesions and three years disease-free period was achieved. CONCLUSION: Although surgery is the standard therapeutic approach, the disease recurs despite multiple surgical attempts. Therefore, we recommend cryotherapy as effective and safe treatment modalities for angiolymphoid hyperplasia with eosinophilia. Knowing the recurring nature of this disease, the patients with angiolymphoid hyperplasia should stay on short-term follow up in order to monitor if new lesions occur.