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High titer MVA and influenza A virus production using a hybrid fed-batch/perfusion strategy with an ATF system

A cultivation strategy to increase the productivity of Modified Vaccinia Ankara (MVA) virus in high-cell density processes is presented. Based on an approach developed in shake flask cultures, this strategy was established in benchtop bioreactors, comprising the growth of suspension AGE1.CR.pIX cell...

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Detalles Bibliográficos
Autores principales:	Vázquez-Ramírez, Daniel, Jordan, Ingo, Sandig, Volker, Genzel, Yvonne, Reichl, Udo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2019
Materias:	Biotechnological Products and Process Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447503/ https://www.ncbi.nlm.nih.gov/pubmed/30796494 http://dx.doi.org/10.1007/s00253-019-09694-2

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