Targeting actin inhibits repair of doxorubicin-induced DNA damage: a novel therapeutic approach for combination therapy

Severe side effects often restrict clinical application of the widely used chemotherapeutic drug doxorubicin. In order to decrease required substance concentrations, new concepts for successful combination therapy are needed. Since doxorubicin causes DNA damage, combination with compounds that modul...

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Detalles Bibliográficos
Autores principales: Pfitzer, Lisa, Moser, Christina, Gegenfurtner, Florian, Arner, Anja, Foerster, Florian, Atzberger, Carina, Zisis, Themistoklis, Kubisch-Dohmen, Rebekka, Busse, Johanna, Smith, Rebecca, Timinszky, Gyula, Kalinina, Olga V., Müller, Rolf, Wagner, Ernst, Vollmar, Angelika M., Zahler, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447524/
https://www.ncbi.nlm.nih.gov/pubmed/30944311
http://dx.doi.org/10.1038/s41419-019-1546-9

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