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VPS33B interacts with NESG1 to modulate EGFR/PI3K/AKT/c-Myc/P53/miR-133a-3p signaling and induce 5-fluorouracil sensitivity in nasopharyngeal carcinoma

The vacuolar protein sorting 33B (VPS33B) was rarely reported in malignant tumors. In this research, we demonstrated that overexpression of VPS33B inhibited proliferation and chemoresistance to fluorouracil (5-FU) in nasopharyngeal carcinoma (NPC) in vivo and in vitro. Mechanistic analysis confirmed...

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Detalles Bibliográficos
Autores principales:	Liang, Zixi, Liu, Zhen, Cheng, Chao, Wang, Hao, Deng, Xiaojie, Liu, Jiahao, Liu, Chen, Li, Yonghao, Fang, Weiyi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447525/ https://www.ncbi.nlm.nih.gov/pubmed/30944308 http://dx.doi.org/10.1038/s41419-019-1457-9

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