MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression

Akt plays indispensable roles in cell proliferation, survival and metabolism. Mechanisms underlying posttranslational modification-mediated Akt activation have been extensively studied yet the Akt interactome is less understood. Here, we report that SAV1, a Hippo signaling component, inhibits Akt, a...

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Detalles Bibliográficos
Autores principales: Jiang, Yao, Zhang, Yanqiong, Leung, Janet Y., Fan, Cheng, Popov, Konstantin I., Su, Siyuan, Qian, Jiayi, Wang, Xiaodong, Holtzhausen, Alisha, Ubil, Eric, Xiang, Yang, Davis, Ian, Dokholyan, Nikolay V., Wu, Gang, Perou, Charles M., Kim, William Y., Earp, H. Shelton, Liu, Pengda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447540/
https://www.ncbi.nlm.nih.gov/pubmed/30944303
http://dx.doi.org/10.1038/s41467-019-09233-7

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