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GRSF1 is an age-related regulator of senescence
Senescent cells that accumulate in multiple tissues with age are thought to increase pathological phenotypes. The removal of senescent cells can improve lifespan and/or healthspan in mouse models. Global hypomethylation and local hypermethylation in DNA are hallmarks of aging but it is unclear if su...
Autores principales: | Kim, Su-Jeong, Chun, Maria, Wan, Junxiang, Lee, Changhan, Yen, Kelvin, Cohen, Pinchas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447602/ https://www.ncbi.nlm.nih.gov/pubmed/30944385 http://dx.doi.org/10.1038/s41598-019-42064-6 |
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