Cargando…

Ca(2+)-dependent regulation of sodium channels Na(V)1.4 and Na(V)1.5 is controlled by the post-IQ motif

Skeletal muscle voltage-gated Na(+) channel (Na(V)1.4) activity is subject to calmodulin (CaM) mediated Ca(2+)-dependent inactivation; no such inactivation is observed in the cardiac Na(+) channel (Na(V)1.5). Taken together, the crystal structures of the Na(V)1.4 C-terminal domain relevant complexes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yoder, Jesse B., Ben-Johny, Manu, Farinelli, Federica, Srinivasan, Lakshmi, Shoemaker, Sophie R., Tomaselli, Gordon F., Gabelli, Sandra B., Amzel, L. Mario
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447637/ https://www.ncbi.nlm.nih.gov/pubmed/30944319 http://dx.doi.org/10.1038/s41467-019-09570-7

Ejemplares similares

Structural basis of cytoplasmic Na(V)1.5 and Na(V)1.4 regulation
por: Nathan, Sara, et al.
Publicado: (2020)

Development of high-affinity nanobodies specific for Na(V)1.4 and Na(V)1.5 voltage-gated sodium channel isoforms
por: Srinivasan, Lakshmi, et al.
Publicado: (2022)

Regulation of the Na(v)1.5 cytoplasmic domain by Calmodulin
por: Gabelli, Sandra B., et al.
Publicado: (2014)

Calmodulin and Ca(2+) control of voltage gated Na(+) channels
por: Gabelli, Sandra B, et al.
Publicado: (2015)

Allosteric regulators selectively prevent Ca(2+)-feedback of Ca(V) and Na(V) channels
por: Niu, Jacqueline, et al.
Publicado: (2018)

The IQ Motif is Crucial for Ca(v)1.1 Function
por: Stroffekova, Katarina
Publicado: (2011)

Na(v)igating the intricacies of cellular machinery
por: Nathan, Sara, et al.
Publicado: (2021)

Calmodulin mutations affecting Gly114 impair binding to the Na(V)1.5 IQ-domain
por: Brohus, Malene, et al.
Publicado: (2023)

Ciguatoxins Evoke Potent CGRP Release by Activation of Voltage-Gated Sodium Channel Subtypes Na(V)1.9, Na(V)1.7 and Na(V)1.1
por: Touska, Filip, et al.
Publicado: (2017)

Tramadol as a Voltage-Gated Sodium Channel Blocker of Peripheral Sodium Channels Na(v)1.7 and Na(v)1.5
por: Bok, Chan-Su, et al.
Publicado: (2023)

Physiological sodium concentrations enhance the iodide affinity of the Na(+)/I(−) symporter
por: Nicola, Juan P., et al.
Publicado: (2014)

Heat-resistant action potentials require TTX-resistant sodium channels Na(V)1.8 and Na(V)1.9
por: Touska, Filip, et al.
Publicado: (2018)

Acidosis Differentially Modulates Inactivation in Na(V)1.2, Na(V)1.4, and Na(V)1.5 Channels
por: Vilin, Yury Y., et al.
Publicado: (2012)

Complementary roles of murine Na(V)1.7, Na(V)1.8 and Na(V)1.9 in acute itch signalling
por: Kühn, Helen, et al.
Publicado: (2020)

Na(v)1.7 and Na(v)1.8: Role in the pathophysiology of pain
por: Hameed, Shaila
Publicado: (2019)

Antillatoxin is a sodium channel activator that displays unique efficacy in heterologously expressed rNa(v)1.2, rNa(v)1.4 and rNa(v)1.5 alpha subunits
por: Cao, Zhengyu, et al.
Publicado: (2010)

Roles of Voltage-Gated Tetrodotoxin-Sensitive Sodium Channels Na(V)1.3 and Na(V)1.7 in Diabetes and Painful Diabetic Neuropathy
por: Yang, Linlin, et al.
Publicado: (2016)

Na(V)1.6 and Na(V)1.7 channels are major endogenous voltage-gated sodium channels in ND7/23 cells
por: Lee, Jisoo, et al.
Publicado: (2019)

An SCN1B Variant Affects Both Cardiac-Type (Na(V)1.5) and Brain-Type (Na(V)1.1) Sodium Currents and Contributes to Complex Concomitant Brain and Cardiac Disorders
por: Martinez-Moreno, Rebecca, et al.
Publicado: (2020)

Chemical shift assignments of the C-terminal domain of CaBP1 bound to the IQ-motif of voltage-gated Ca(2+) channel (Ca(V)1.2)
por: Salveson, Ian, et al.
Publicado: (2022)

K(V)4.3 Expression Modulates Na(V)1.5 Sodium Current
por: Portero, Vincent, et al.
Publicado: (2018)

Osteoarthritis-dependent changes in antinociceptive action of Na(v)1.7 and Na(v)1.8 sodium channel blockers: An in vivo electrophysiological study in the rat
por: Rahman, W., et al.
Publicado: (2015)

Calmodulin Regulation of Na(V)1.4 Current: Role of Binding to the Carboxyl Terminus
por: Biswas, Subrata, et al.
Publicado: (2008)

Editorial: Inherited Arrhythmias of the Cardiac Sodium Channel Na(v)1.5
por: Amarouch, Mohamed-Yassine, et al.
Publicado: (2021)

Conserved but not critical: Trafficking and function of Na(V)1.7 are independent of highly conserved polybasic motifs
por: Tyagi, Sidharth, et al.
Publicado: (2023)

Mechanisms of a Human Skeletal Myotonia Produced by Mutation in the C-Terminus of Na(V)1.4: Is Ca(2+) Regulation Defective?
por: Biswas, Subrata, et al.
Publicado: (2013)

The trafficking of Na(V)1.8
por: Swanwick, Richard S., et al.
Publicado: (2010)

Cold sensing by Na(V)1.8-positive and Na(V)1.8-negative sensory neurons
por: Luiz, A. P., et al.
Publicado: (2019)

Chemometric Models of Differential Amino Acids at the Na(v)α and Na(v)β Interface of Mammalian Sodium Channel Isoforms
por: Villa-Diaz, Fernando, et al.
Publicado: (2020)

Sodium channel Na(V)1.3 is important for enterochromaffin cell excitability and serotonin release
por: Strege, Peter R., et al.
Publicado: (2017)

Sodium channel Na(v)1.8 immunoreactivity in painful human dental pulp
por: Renton, T, et al.
Publicado: (2005)

Sodium channel Na(v)1.6 accumulates at the site of infraorbital nerve injury
por: Henry, Michael A, et al.
Publicado: (2007)

Na(v)1.7 is the predominant sodium channel in rodent olfactory sensory neurons
por: Ahn, Hye-Sook, et al.
Publicado: (2011)

Mechanism of sodium channel Na(V)1.9 potentiation by G-protein signaling
por: Vanoye, Carlos G., et al.
Publicado: (2013)

Proton-dependent inhibition of the cardiac sodium channel Na(v)1.5 by ranolazine
por: Sokolov, S., et al.
Publicado: (2013)

Systematic Study of Binding of µ-Conotoxins to the Sodium Channel Na(V)1.4
por: Mahdavi, Somayeh, et al.
Publicado: (2014)

The Voltage-Gated Sodium Channel Na(v)1.8 Is Expressed in Human Sperm
por: Cejudo-Roman, Antonio, et al.
Publicado: (2013)

Mutations in Na(V)1.5 Reveal Calcium-Calmodulin Regulation of Sodium Channel
por: Nof, Eyal, et al.
Publicado: (2019)

The voltage-gated sodium channel Na(v)1.7 associated with endometrial cancer
por: Liu, Junxiu, et al.
Publicado: (2019)

Life Cycle of the Cardiac Voltage-Gated Sodium Channel Na(V)1.5
por: Dong, Caijuan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_h8am0tgsemgo9hvu60qolhuvk3