The Fish-Specific Protein Kinase (PKZ) Initiates Innate Immune Responses via IRF3- and ISGF3-Like Mediated Pathways

PKZ is a fish-specific protein kinase containing Zα domains. PKZ is known to induce apoptosis through phosphorylating eukaryotic initiation factor 2α kinase (eIF2α) in the same way as double-stranded RNA-dependent protein kinase (PKR), but its exact role in detecting pathogens remains to be fully el...

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Autores principales: Xu, Xiaowen, Li, Meifeng, Wu, Chuxin, Li, Dongming, Jiang, Zeyin, Liu, Changxin, Cheng, Bo, Mao, Huiling, Hu, Chengyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447671/
https://www.ncbi.nlm.nih.gov/pubmed/30984174
http://dx.doi.org/10.3389/fimmu.2019.00582

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