Advancements and Obstacles of CRISPR-Cas9 Technology in Translational Research

The expanding CRISPR-Cas9 technology is an easily accessible, programmable, and precise gene-editing tool with numerous applications, most notably in biomedical research. Together with advancements in genome and transcriptome sequencing in the era of metadata, genomic engineering with CRISPR-Cas9 me...

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Detalles Bibliográficos
Autores principales: You, Liting, Tong, Ruizhan, Li, Mengqian, Liu, Yuncong, Xue, Jianxin, Lu, You
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447755/
https://www.ncbi.nlm.nih.gov/pubmed/30989086
http://dx.doi.org/10.1016/j.omtm.2019.02.008
Descripción
Sumario:The expanding CRISPR-Cas9 technology is an easily accessible, programmable, and precise gene-editing tool with numerous applications, most notably in biomedical research. Together with advancements in genome and transcriptome sequencing in the era of metadata, genomic engineering with CRISPR-Cas9 meets the developmental requirements of precision medicine, and clinical tests using CRISPR-Cas9 are now possible. This review summarizes developments and established preclinical applications of CRISPR-Cas9 technology, along with its current challenges, and highlights future applications in translational research.

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