Advancements and Obstacles of CRISPR-Cas9 Technology in Translational Research

The expanding CRISPR-Cas9 technology is an easily accessible, programmable, and precise gene-editing tool with numerous applications, most notably in biomedical research. Together with advancements in genome and transcriptome sequencing in the era of metadata, genomic engineering with CRISPR-Cas9 me...

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Detalles Bibliográficos
Autores principales: You, Liting, Tong, Ruizhan, Li, Mengqian, Liu, Yuncong, Xue, Jianxin, Lu, You
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447755/
https://www.ncbi.nlm.nih.gov/pubmed/30989086
http://dx.doi.org/10.1016/j.omtm.2019.02.008
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author You, Liting
Tong, Ruizhan
Li, Mengqian
Liu, Yuncong
Xue, Jianxin
Lu, You
author_facet You, Liting
Tong, Ruizhan
Li, Mengqian
Liu, Yuncong
Xue, Jianxin
Lu, You
author_sort You, Liting
collection PubMed
description The expanding CRISPR-Cas9 technology is an easily accessible, programmable, and precise gene-editing tool with numerous applications, most notably in biomedical research. Together with advancements in genome and transcriptome sequencing in the era of metadata, genomic engineering with CRISPR-Cas9 meets the developmental requirements of precision medicine, and clinical tests using CRISPR-Cas9 are now possible. This review summarizes developments and established preclinical applications of CRISPR-Cas9 technology, along with its current challenges, and highlights future applications in translational research.
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spelling pubmed-64477552019-04-15 Advancements and Obstacles of CRISPR-Cas9 Technology in Translational Research You, Liting Tong, Ruizhan Li, Mengqian Liu, Yuncong Xue, Jianxin Lu, You Mol Ther Methods Clin Dev Article The expanding CRISPR-Cas9 technology is an easily accessible, programmable, and precise gene-editing tool with numerous applications, most notably in biomedical research. Together with advancements in genome and transcriptome sequencing in the era of metadata, genomic engineering with CRISPR-Cas9 meets the developmental requirements of precision medicine, and clinical tests using CRISPR-Cas9 are now possible. This review summarizes developments and established preclinical applications of CRISPR-Cas9 technology, along with its current challenges, and highlights future applications in translational research. American Society of Gene & Cell Therapy 2019-03-15 /pmc/articles/PMC6447755/ /pubmed/30989086 http://dx.doi.org/10.1016/j.omtm.2019.02.008 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
You, Liting
Tong, Ruizhan
Li, Mengqian
Liu, Yuncong
Xue, Jianxin
Lu, You
Advancements and Obstacles of CRISPR-Cas9 Technology in Translational Research
title Advancements and Obstacles of CRISPR-Cas9 Technology in Translational Research
title_full Advancements and Obstacles of CRISPR-Cas9 Technology in Translational Research
title_fullStr Advancements and Obstacles of CRISPR-Cas9 Technology in Translational Research
title_full_unstemmed Advancements and Obstacles of CRISPR-Cas9 Technology in Translational Research
title_short Advancements and Obstacles of CRISPR-Cas9 Technology in Translational Research
title_sort advancements and obstacles of crispr-cas9 technology in translational research
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447755/
https://www.ncbi.nlm.nih.gov/pubmed/30989086
http://dx.doi.org/10.1016/j.omtm.2019.02.008
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