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Protective effects of leptin against cerebral ischemia/reperfusion injury

In recent years, the use of thrombolytic therapy for treating ischemia/reperfusion injury has resulted in damage to the self-regulatory mechanisms of the brain. This is due to the increased production of free radicals, excitatory amino acids and pro-inflammatory cytokines causing secondary damage to...

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Autores principales: Zhang, Wen-Fang, Jin, Yin-Chuan, Li, Xiao-Mei, Yang, Zhi, Wang, Dong, Cui, Jing-Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447799/
https://www.ncbi.nlm.nih.gov/pubmed/30988703
http://dx.doi.org/10.3892/etm.2019.7377
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author Zhang, Wen-Fang
Jin, Yin-Chuan
Li, Xiao-Mei
Yang, Zhi
Wang, Dong
Cui, Jing-Jing
author_facet Zhang, Wen-Fang
Jin, Yin-Chuan
Li, Xiao-Mei
Yang, Zhi
Wang, Dong
Cui, Jing-Jing
author_sort Zhang, Wen-Fang
collection PubMed
description In recent years, the use of thrombolytic therapy for treating ischemia/reperfusion injury has resulted in damage to the self-regulatory mechanisms of the brain. This is due to the increased production of free radicals, excitatory amino acids and pro-inflammatory cytokines causing secondary damage to the brain. Simple thrombolytic therapy has not been the best approach for treating ischemia/reperfusion injury. Excessive perfusion leads to failure of the body's self-regulatory functions, which in turn increases the area of cerebral edema and aggravates cerebral ischemia. Previous studies have evaluated the satiety hormone leptin as a link between energy expenditure and obesity. Of note, leptin, which is involved in brain development, synaptic transmission and angiogenesis following ischemia/reperfusion injury, has been considered an important factor for treating ischemia/reperfusion injury. The present review outlines the discovery of leptin and discusses its association with cerebral ischemia/reperfusion.
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spelling pubmed-64477992019-04-15 Protective effects of leptin against cerebral ischemia/reperfusion injury Zhang, Wen-Fang Jin, Yin-Chuan Li, Xiao-Mei Yang, Zhi Wang, Dong Cui, Jing-Jing Exp Ther Med Review In recent years, the use of thrombolytic therapy for treating ischemia/reperfusion injury has resulted in damage to the self-regulatory mechanisms of the brain. This is due to the increased production of free radicals, excitatory amino acids and pro-inflammatory cytokines causing secondary damage to the brain. Simple thrombolytic therapy has not been the best approach for treating ischemia/reperfusion injury. Excessive perfusion leads to failure of the body's self-regulatory functions, which in turn increases the area of cerebral edema and aggravates cerebral ischemia. Previous studies have evaluated the satiety hormone leptin as a link between energy expenditure and obesity. Of note, leptin, which is involved in brain development, synaptic transmission and angiogenesis following ischemia/reperfusion injury, has been considered an important factor for treating ischemia/reperfusion injury. The present review outlines the discovery of leptin and discusses its association with cerebral ischemia/reperfusion. D.A. Spandidos 2019-05 2019-03-13 /pmc/articles/PMC6447799/ /pubmed/30988703 http://dx.doi.org/10.3892/etm.2019.7377 Text en Copyright: © Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Zhang, Wen-Fang
Jin, Yin-Chuan
Li, Xiao-Mei
Yang, Zhi
Wang, Dong
Cui, Jing-Jing
Protective effects of leptin against cerebral ischemia/reperfusion injury
title Protective effects of leptin against cerebral ischemia/reperfusion injury
title_full Protective effects of leptin against cerebral ischemia/reperfusion injury
title_fullStr Protective effects of leptin against cerebral ischemia/reperfusion injury
title_full_unstemmed Protective effects of leptin against cerebral ischemia/reperfusion injury
title_short Protective effects of leptin against cerebral ischemia/reperfusion injury
title_sort protective effects of leptin against cerebral ischemia/reperfusion injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447799/
https://www.ncbi.nlm.nih.gov/pubmed/30988703
http://dx.doi.org/10.3892/etm.2019.7377
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