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Pharmacokinetics and Biodistribution of Pegylated Methotrexate after IV Administration to Mice

The efficacy of methotrexate (MTX) as an antimetabolite chemotherapeutic agent highly depends on its blood circulation half-life. In our previous study, different conjugates of MTX (MTX-PEG) were synthesized, their physicochemical properties were investigated and MTX-PEG5000 was finally selected as...

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Detalles Bibliográficos
Autores principales:	Yousefi, Gholamhossein, Shafaati, Alireza, Zarghi, Afshin, Foroutan, Seyed Mohsen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Shaheed Beheshti University of Medical Sciences 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447882/ https://www.ncbi.nlm.nih.gov/pubmed/31011346

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