Krüppel‐like factor 2 inhibits hepatocarcinogenesis through negative regulation of the Hedgehog pathway

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. The most important reason for the occurrence of HCC is hepatitis C or B infection. Moreover, genetic factors play an important role in the tumorigenesis of HCC. Here, we demonstrated that Krüppel‐like factor 2 (KLF2) ex...

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Autores principales: Lin, JinBo, Tan, Huifang, Nie, Yingjie, Wu, Dongwen, Zheng, Weiji, Lin, Wensong, Zhu, Zheng, Yang, Bing, Chen, Xiaoliang, Chen, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447955/
https://www.ncbi.nlm.nih.gov/pubmed/30719823
http://dx.doi.org/10.1111/cas.13961
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author Lin, JinBo
Tan, Huifang
Nie, Yingjie
Wu, Dongwen
Zheng, Weiji
Lin, Wensong
Zhu, Zheng
Yang, Bing
Chen, Xiaoliang
Chen, Tao
author_facet Lin, JinBo
Tan, Huifang
Nie, Yingjie
Wu, Dongwen
Zheng, Weiji
Lin, Wensong
Zhu, Zheng
Yang, Bing
Chen, Xiaoliang
Chen, Tao
author_sort Lin, JinBo
collection PubMed
description Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. The most important reason for the occurrence of HCC is hepatitis C or B infection. Moreover, genetic factors play an important role in the tumorigenesis of HCC. Here, we demonstrated that Krüppel‐like factor 2 (KLF2) expression was downregulated in HCC samples compared with adjacent tissues. Additionally, KLF2 was shown to inhibit the growth, migration and colony‐formation ability of liver cancer cells. Further mechanistic studies revealed that KLF2 can compete with Gli1 for interaction with HDAC1 and restrains Hedgehog signal activation. Together, our results suggest that KLF2 has potential as a diagnostic biomarker and therapeutic target for the treatment of HCC.
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spelling pubmed-64479552019-04-15 Krüppel‐like factor 2 inhibits hepatocarcinogenesis through negative regulation of the Hedgehog pathway Lin, JinBo Tan, Huifang Nie, Yingjie Wu, Dongwen Zheng, Weiji Lin, Wensong Zhu, Zheng Yang, Bing Chen, Xiaoliang Chen, Tao Cancer Sci Original Articles Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. The most important reason for the occurrence of HCC is hepatitis C or B infection. Moreover, genetic factors play an important role in the tumorigenesis of HCC. Here, we demonstrated that Krüppel‐like factor 2 (KLF2) expression was downregulated in HCC samples compared with adjacent tissues. Additionally, KLF2 was shown to inhibit the growth, migration and colony‐formation ability of liver cancer cells. Further mechanistic studies revealed that KLF2 can compete with Gli1 for interaction with HDAC1 and restrains Hedgehog signal activation. Together, our results suggest that KLF2 has potential as a diagnostic biomarker and therapeutic target for the treatment of HCC. John Wiley and Sons Inc. 2019-03-04 2019-04 /pmc/articles/PMC6447955/ /pubmed/30719823 http://dx.doi.org/10.1111/cas.13961 Text en © 2019 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Lin, JinBo
Tan, Huifang
Nie, Yingjie
Wu, Dongwen
Zheng, Weiji
Lin, Wensong
Zhu, Zheng
Yang, Bing
Chen, Xiaoliang
Chen, Tao
Krüppel‐like factor 2 inhibits hepatocarcinogenesis through negative regulation of the Hedgehog pathway
title Krüppel‐like factor 2 inhibits hepatocarcinogenesis through negative regulation of the Hedgehog pathway
title_full Krüppel‐like factor 2 inhibits hepatocarcinogenesis through negative regulation of the Hedgehog pathway
title_fullStr Krüppel‐like factor 2 inhibits hepatocarcinogenesis through negative regulation of the Hedgehog pathway
title_full_unstemmed Krüppel‐like factor 2 inhibits hepatocarcinogenesis through negative regulation of the Hedgehog pathway
title_short Krüppel‐like factor 2 inhibits hepatocarcinogenesis through negative regulation of the Hedgehog pathway
title_sort krüppel‐like factor 2 inhibits hepatocarcinogenesis through negative regulation of the hedgehog pathway
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447955/
https://www.ncbi.nlm.nih.gov/pubmed/30719823
http://dx.doi.org/10.1111/cas.13961
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