MicroRNA-216a suppresses the proliferation and migration of human breast cancer cells via the Wnt/β-catenin signaling pathway

The aim of the present study was to investigate the potential anticancer effects of microRNA-216a on the growth of human breast cancer and the possible underlying mechanisms. The results demonstrated that serum microRNA-216a was significantly decreased in patients with breast cancer compared with he...

Descripción completa

Detalles Bibliográficos
Autores principales: Xie, Qing, Wang, Shuai, Zhao, Yue, Zhang, Zhenchao, Qin, Chuan, Yang, Xianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448085/
https://www.ncbi.nlm.nih.gov/pubmed/30864744
http://dx.doi.org/10.3892/or.2019.7050
_version_ 1783408628156334080
author Xie, Qing
Wang, Shuai
Zhao, Yue
Zhang, Zhenchao
Qin, Chuan
Yang, Xianjun
author_facet Xie, Qing
Wang, Shuai
Zhao, Yue
Zhang, Zhenchao
Qin, Chuan
Yang, Xianjun
author_sort Xie, Qing
collection PubMed
description The aim of the present study was to investigate the potential anticancer effects of microRNA-216a on the growth of human breast cancer and the possible underlying mechanisms. The results demonstrated that serum microRNA-216a was significantly decreased in patients with breast cancer compared with healthy controls. MicroRNA-216a overexpression led to a decrease in cell proliferation and migration, as well as increases in apoptosis, caspase-3/8 activities, Bax expression and p53 protein expression in MCF-7 cells. It was also revealed that microRNA-216a suppressed Wnt and β-catenin expression in MCF-7 cells. The anticancer effects of microRNA-216a were reversed by anti-microRNA-216a by promoting the Wnt/β-catenin signaling pathway. Inactivation of the Wnt pathway increased the anticancer effects of microRNA-216a in MCF-7 cells. Collectively, the results of the present study indicated that microRNA-216a suppressed the growth of human breast cancer cells by targeting the Wnt/β-catenin signaling pathway.
format Online
Article
Text
id pubmed-6448085
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher D.A. Spandidos
record_format MEDLINE/PubMed
spelling pubmed-64480852019-04-15 MicroRNA-216a suppresses the proliferation and migration of human breast cancer cells via the Wnt/β-catenin signaling pathway Xie, Qing Wang, Shuai Zhao, Yue Zhang, Zhenchao Qin, Chuan Yang, Xianjun Oncol Rep Articles The aim of the present study was to investigate the potential anticancer effects of microRNA-216a on the growth of human breast cancer and the possible underlying mechanisms. The results demonstrated that serum microRNA-216a was significantly decreased in patients with breast cancer compared with healthy controls. MicroRNA-216a overexpression led to a decrease in cell proliferation and migration, as well as increases in apoptosis, caspase-3/8 activities, Bax expression and p53 protein expression in MCF-7 cells. It was also revealed that microRNA-216a suppressed Wnt and β-catenin expression in MCF-7 cells. The anticancer effects of microRNA-216a were reversed by anti-microRNA-216a by promoting the Wnt/β-catenin signaling pathway. Inactivation of the Wnt pathway increased the anticancer effects of microRNA-216a in MCF-7 cells. Collectively, the results of the present study indicated that microRNA-216a suppressed the growth of human breast cancer cells by targeting the Wnt/β-catenin signaling pathway. D.A. Spandidos 2019-05 2019-03-07 /pmc/articles/PMC6448085/ /pubmed/30864744 http://dx.doi.org/10.3892/or.2019.7050 Text en Copyright: © Xie et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Xie, Qing
Wang, Shuai
Zhao, Yue
Zhang, Zhenchao
Qin, Chuan
Yang, Xianjun
MicroRNA-216a suppresses the proliferation and migration of human breast cancer cells via the Wnt/β-catenin signaling pathway
title MicroRNA-216a suppresses the proliferation and migration of human breast cancer cells via the Wnt/β-catenin signaling pathway
title_full MicroRNA-216a suppresses the proliferation and migration of human breast cancer cells via the Wnt/β-catenin signaling pathway
title_fullStr MicroRNA-216a suppresses the proliferation and migration of human breast cancer cells via the Wnt/β-catenin signaling pathway
title_full_unstemmed MicroRNA-216a suppresses the proliferation and migration of human breast cancer cells via the Wnt/β-catenin signaling pathway
title_short MicroRNA-216a suppresses the proliferation and migration of human breast cancer cells via the Wnt/β-catenin signaling pathway
title_sort microrna-216a suppresses the proliferation and migration of human breast cancer cells via the wnt/β-catenin signaling pathway
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448085/
https://www.ncbi.nlm.nih.gov/pubmed/30864744
http://dx.doi.org/10.3892/or.2019.7050
work_keys_str_mv AT xieqing microrna216asuppressestheproliferationandmigrationofhumanbreastcancercellsviathewntbcateninsignalingpathway
AT wangshuai microrna216asuppressestheproliferationandmigrationofhumanbreastcancercellsviathewntbcateninsignalingpathway
AT zhaoyue microrna216asuppressestheproliferationandmigrationofhumanbreastcancercellsviathewntbcateninsignalingpathway
AT zhangzhenchao microrna216asuppressestheproliferationandmigrationofhumanbreastcancercellsviathewntbcateninsignalingpathway
AT qinchuan microrna216asuppressestheproliferationandmigrationofhumanbreastcancercellsviathewntbcateninsignalingpathway
AT yangxianjun microrna216asuppressestheproliferationandmigrationofhumanbreastcancercellsviathewntbcateninsignalingpathway

Ejemplares similares