Cargando…

PLCε promotes urinary bladder cancer cells proliferation through STAT3/LDHA pathway-mediated glycolysis

Phospholipase Cε (PLCε) and anaerobic glycolysis were determined to be involved in the development of human urinary bladder cancer (UBC), but the mechanisms remain unclear. In the present study, 64 bladder cancer specimens and 42 adjacent tissue specimens were obtained from 64 patients, and immunoch...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Honglin, Hao, Yanni, Gao, Yingying, He, Yunfeng, Luo, Chunli, Sun, Wei, Yuan, Mengjuan, Wu, Xiaohou
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448096/ https://www.ncbi.nlm.nih.gov/pubmed/30864733 http://dx.doi.org/10.3892/or.2019.7056

Ejemplares similares

PLCε regulates prostate cancer mitochondrial oxidative metabolism and migration via upregulation of Twist1
por: Fan, Jiaxin, et al.
Publicado: (2019)

Combination of phospholipase Cε knockdown with GANT61 sensitizes castration-resistant prostate cancer cells to enzalutamide by suppressing the androgen receptor signaling pathway
por: Sun, Wei, et al.
Publicado: (2019)

Combination of phospholipase Cε knockdown with GANT61 sensitizes castration-resistant prostate cancer cells to enzalutamide by suppressing the androgen receptor signaling pathway
por: Sun, Wei, et al.
Publicado: (2022)

Inhibitor 9 Combined With Androgen Deprivation Therapy or Chemotherapy Delays the Malignant Behavior of Castration-Resistant Prostate Cancer Through K-Ras/PLCε/PKCε Signaling Pathway
por: Liu, Jiayu, et al.
Publicado: (2020)

PLCε knockdown enhances the radiosensitivity of castration-resistant prostate cancer via the AR/PARP1/DNA-PKcs axis
por: Pu, Jun, et al.
Publicado: (2020)

PLCε knockdown enhances the radiosensitivity of castration-resistant prostate cancer via the AR/PARP1/DNA-PKcs axis
por: Pu, Jun, et al.
Publicado: (2022)

Phospholipase C (PLC)ɛ Promotes Androgen Receptor Antagonist Resistance via the Bone Morphogenetic Protein (BMP)-6/SMAD Axis in a Castration-Resistant Prostate Cancer Cell Line
por: Yuan, Mengjuan, et al.
Publicado: (2019)

CDKN3 Overcomes Bladder Cancer Cisplatin Resistance via LDHA-Dependent Glycolysis Reprogramming
por: Li, Mengxuan, et al.
Publicado: (2022)

The miR-383-LDHA axis regulates cell proliferation, invasion and glycolysis in hepatocellular cancer
por: Fang, Zhixiong, et al.
Publicado: (2017)

STAT3/LINC00671 axis regulates papillary thyroid tumor growth and metastasis via LDHA-mediated glycolysis
por: Huo, Nan, et al.
Publicado: (2021)

Functional significance of the hepaCAM gene in bladder cancer
por: He, Yunfeng, et al.
Publicado: (2010)

Circular RNA circVAMP3 promotes aerobic glycolysis and proliferation by regulating LDHA in renal cell carcinoma
por: Li, Jun, et al.
Publicado: (2022)

Long noncoding RNA HOTAIR regulates the invasion and metastasis of prostate cancer by targeting hepaCAM
por: Li, Ting, et al.
Publicado: (2020)

In vitro and in vivo studies of pirarubicin-loaded SWNT for the treatment of bladder cancer
por: Chen, Gang, et al.
Publicado: (2012)

FOXQ1 promotes pancreatic cancer cell proliferation, tumor stemness, invasion and metastasis through regulation of LDHA-mediated aerobic glycolysis
por: Wu, Changhao, et al.
Publicado: (2023)

MiR-638 Repressed Vascular Smooth Muscle Cell Glycolysis by Targeting LDHA
por: Chen, Shiyuan, et al.
Publicado: (2019)

MiR-489-3p Reduced Pancreatic Cancer Proliferation and Metastasis By Targeting PKM2 and LDHA Involving Glycolysis
por: Zhang, Dan, et al.
Publicado: (2021)

Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2
por: Wang, Chunqing, et al.
Publicado: (2020)

Hypoxia‐induced FOXO4/LDHA axis modulates gastric cancer cell glycolysis and progression
por: Wang, Xiao‐Hong, et al.
Publicado: (2021)

Impaired Delta Np63 Expression is Associated with Poor Tumor Development in Transitional Cell Carcinoma of the Bladder
por: He, Yunfeng, et al.
Publicado: (2008)

Knockdown of Phospholipase Cɛ (PLCɛ) Inhibits Cell Proliferation via Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN)/AKT Signaling Pathway in Human Prostate Cancer
por: Wang, Xiao, et al.
Publicado: (2018)

The c-Myc–LDHA axis positively regulates aerobic glycolysis and promotes tumor progression in pancreatic cancer
por: He, Tian-Lin, et al.
Publicado: (2015)

PCK1 Regulates Glycolysis and Tumor Progression in Clear Cell Renal Cell Carcinoma Through LDHA
por: Shi, Liang, et al.
Publicado: (2020)

LDHA Promotes Oral Squamous Cell Carcinoma Progression Through Facilitating Glycolysis and Epithelial–Mesenchymal Transition
por: Cai, Hongshi, et al.
Publicado: (2019)

Indole-3-Carbinol Stabilizes p53 to Induce miR-34a, Which Targets LDHA to Block Aerobic Glycolysis in Liver Cancer Cells
por: Qi, Yuehua, et al.
Publicado: (2022)

Starvation induced autophagy promotes the progression of bladder cancer by LDHA mediated metabolic reprogramming
por: Li, Tinghao, et al.
Publicado: (2021)

The controversial role of phospholipase C epsilon (PLCε) in cancer development and progression
por: Tyutyunnykova, Anna, et al.
Publicado: (2017)

TOP1MT deficiency promotes GC invasion and migration via the enhancements of LDHA expression and aerobic glycolysis
por: Wang, Hongqiang, et al.
Publicado: (2017)

FAM46B Promotes Apoptosis and Inhibits Glycolysis of Prostate Cancer Through Inhibition of the MYC-LDHA Axis
por: Liang, Tao, et al.
Publicado: (2020)

MYC Promotes LDHA Expression through MicroRNA-122-5p to Potentiate Glycolysis in Hepatocellular Carcinoma
por: Wang, Xiaofei, et al.
Publicado: (2022)

Circular RNA, circular RARS, promotes aerobic glycolysis of non‐small‐cell lung cancer by binding with LDHA
por: Li, Haoran, et al.
Publicado: (2023)

Long non-coding RNA CCHE1 modulates LDHA-mediated glycolysis and confers chemoresistance to melanoma cells
por: Ding, Zhi, et al.
Publicado: (2023)

Phospholipase Cɛ Regulates Prostate Cancer Lipid Metabolism and Proliferation by Targeting AMP-Activated Protein Kinase (AMPK)/Sterol Regulatory Element-Binding Protein 1 (SREBP-1) Signaling Pathway
por: Zheng, Yongbo, et al.
Publicado: (2020)

Pancreatic stellate cell-induced gemcitabine resistance in pancreatic cancer is associated with LDHA- and MCT4-mediated enhanced glycolysis
por: Amrutkar, Manoj, et al.
Publicado: (2023)

USP1 promotes the aerobic glycolysis and progression of T-cell acute lymphoblastic leukemia via PLK1/LDHA axis
por: Liu, Shuguang, et al.
Publicado: (2023)

SUMOylation of PDGF receptor α affects signaling via PLCγ and STAT3, and cell proliferation
por: Wang, Kehuan, et al.
Publicado: (2023)

Curcumin Antagonizes Glucose Fluctuation-Induced Renal Injury by Inhibiting Aerobic Glycolysis via the miR-489/LDHA Pathway
por: Fu, Xiaomei, et al.
Publicado: (2021)

HepaCAM inhibits the malignant behavior of castration-resistant prostate cancer cells by downregulating Notch signaling and PF-3084014 (a γ-secretase inhibitor) partly reverses the resistance of refractory prostate cancer to docetaxel and enzalutamide in vitro
por: Du, Zhongbo, et al.
Publicado: (2018)

Antisense oligonucleotide targeting Livin induces apoptosis of human bladder cancer cell via a mechanism involving caspase 3
por: Chuan, Liu, et al.
Publicado: (2010)

Nuclear Translocation of LDHA Promotes the Catabolism of BCAAs to Sustain GBM Cell Proliferation through the TxN Antioxidant Pathway
por: Li, Zhujun, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_tsesircvq6k0ldvl5tl5lrl94q