The ARTS of Cell Death

Although much is known regarding intestinal stem cell (ISC) self-renewal and differentiation, the specific mechanisms used for their elimination is unclear. We recently discovered that the pro-apoptotic protein ARTS, a Septin4 isoform, interacts with X-linked inhibitor of apoptosis (XIAP) in the ISC...

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Detalles Bibliográficos
Autores principales: Koren, Elle, Fuchs, Yaron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448113/
https://www.ncbi.nlm.nih.gov/pubmed/30983862
http://dx.doi.org/10.1177/1179066019836967
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author Koren, Elle
Fuchs, Yaron
author_facet Koren, Elle
Fuchs, Yaron
author_sort Koren, Elle
collection PubMed
description Although much is known regarding intestinal stem cell (ISC) self-renewal and differentiation, the specific mechanisms used for their elimination is unclear. We recently discovered that the pro-apoptotic protein ARTS, a Septin4 isoform, interacts with X-linked inhibitor of apoptosis (XIAP) in the ISC niche to regulate stem cell survival during intestinal homeostasis and regeneration. These findings point to an intriguing avenue of translational research, examining how manipulation of stem cell apoptosis through the ARTS/XIAP module can affect stem-cell-dependent processes.
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spelling pubmed-64481132019-04-12 The ARTS of Cell Death Koren, Elle Fuchs, Yaron J Cell Death Commentary Although much is known regarding intestinal stem cell (ISC) self-renewal and differentiation, the specific mechanisms used for their elimination is unclear. We recently discovered that the pro-apoptotic protein ARTS, a Septin4 isoform, interacts with X-linked inhibitor of apoptosis (XIAP) in the ISC niche to regulate stem cell survival during intestinal homeostasis and regeneration. These findings point to an intriguing avenue of translational research, examining how manipulation of stem cell apoptosis through the ARTS/XIAP module can affect stem-cell-dependent processes. SAGE Publications 2019-04-03 /pmc/articles/PMC6448113/ /pubmed/30983862 http://dx.doi.org/10.1177/1179066019836967 Text en © The Author(s) 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Commentary
Koren, Elle
Fuchs, Yaron
The ARTS of Cell Death
title The ARTS of Cell Death
title_full The ARTS of Cell Death
title_fullStr The ARTS of Cell Death
title_full_unstemmed The ARTS of Cell Death
title_short The ARTS of Cell Death
title_sort arts of cell death
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448113/
https://www.ncbi.nlm.nih.gov/pubmed/30983862
http://dx.doi.org/10.1177/1179066019836967
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