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Impact of Ferroquine on the Solubilization of Artefenomel (OZ439) during in Vitro Lipolysis in Milk and Implications for Oral Combination Therapy for Malaria

[Image: see text] Milk is an attractive lipid-based formulation for the delivery of poorly water-soluble drugs to pediatric populations. We recently observed that solubilization of artefenomel (OZ439) during in vitro intestinal lipolysis was driven by digestion of triglycerides in full-cream bovine...

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Detalles Bibliográficos
Autores principales:	Salim, Malinda, Khan, Jamal, Ramirez, Gisela, Murshed, Mubtasim, Clulow, Andrew J., Hawley, Adrian, Ramachandruni, Hanu, Beilles, Stephane, Boyd, Ben J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448114/ https://www.ncbi.nlm.nih.gov/pubmed/30830789 http://dx.doi.org/10.1021/acs.molpharmaceut.8b01333

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