Two-stage optimal designs with survival endpoint when the follow-up time is restricted

BACKGROUND: Survival endpoint is frequently used in early phase clinical trials as the primary endpoint to assess the activity of a new treatment. Existing two-stage optimal designs with survival endpoint either over estimate the sample size or compute power outside the alternative hypothesis space....

Descripción completa

Detalles Bibliográficos
Autores principales: Shan, Guogen, Zhang, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448233/
https://www.ncbi.nlm.nih.gov/pubmed/30943896
http://dx.doi.org/10.1186/s12874-019-0696-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448233/
https://www.ncbi.nlm.nih.gov/pubmed/30943896
http://dx.doi.org/10.1186/s12874-019-0696-x

Ejemplares similares