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Sleep and cognitive aging in the eighth decade of life

We examined associations between self-reported sleep measures and cognitive level and change (age 70–76 years) in a longitudinal, same-year-of-birth cohort study (baseline N = 1091; longitudinal N = 664). We also leveraged GWAS summary data to ascertain whether polygenic scores (PGS) of chronotype a...

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Autores principales: Cox, Simon R, Ritchie, Stuart J, Allerhand, Mike, Hagenaars, Saskia P, Radakovic, Ratko, Breen, David P, Davies, Gail, Riha, Renata L, Harris, Sarah E, Starr, John M, Deary, Ian J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448287/
https://www.ncbi.nlm.nih.gov/pubmed/30668819
http://dx.doi.org/10.1093/sleep/zsz019
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author Cox, Simon R
Ritchie, Stuart J
Allerhand, Mike
Hagenaars, Saskia P
Radakovic, Ratko
Breen, David P
Davies, Gail
Riha, Renata L
Harris, Sarah E
Starr, John M
Deary, Ian J
author_facet Cox, Simon R
Ritchie, Stuart J
Allerhand, Mike
Hagenaars, Saskia P
Radakovic, Ratko
Breen, David P
Davies, Gail
Riha, Renata L
Harris, Sarah E
Starr, John M
Deary, Ian J
author_sort Cox, Simon R
collection PubMed
description We examined associations between self-reported sleep measures and cognitive level and change (age 70–76 years) in a longitudinal, same-year-of-birth cohort study (baseline N = 1091; longitudinal N = 664). We also leveraged GWAS summary data to ascertain whether polygenic scores (PGS) of chronotype and sleep duration related to self-reported sleep, and to cognitive level and change. Shorter sleep latency was associated with significantly higher levels of visuospatial ability, processing speed, and verbal memory (β ≥ |0.184|, SE ≤ 0.075, p ≤ 0.003). Longer daytime sleep duration was significantly associated slower processing speed (β = −0.085, SE = 0.027, p = 0.001), and with steeper 6-year decline in visuospatial reasoning (β = −0.009, SE = 0.003, p = 0.008), and processing speed (β = −0.009, SE = 0.002, p < 0.001). Only longitudinal associations between longer daytime sleeping and steeper cognitive declines survived correction for important health covariates and false discovery rate (FDR). PGS of chronotype and sleep duration were nominally associated with specific self-reported sleep characteristics for most SNP thresholds (standardized β range = |0.123 to 0.082|, p range = 0.003 to 0.046), but neither PGS predicted cognitive level or change following FDR. Daytime sleep duration is a potentially important correlate of cognitive decline in visuospatial reasoning and processing speed in older age, whereas cross-sectional associations are partially confounded by important health factors. A genetic propensity toward morningness and sleep duration were weakly, but consistently, related to self-reported sleep characteristics, and did not relate to cognitive level or change.
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spelling pubmed-64482872019-04-08 Sleep and cognitive aging in the eighth decade of life Cox, Simon R Ritchie, Stuart J Allerhand, Mike Hagenaars, Saskia P Radakovic, Ratko Breen, David P Davies, Gail Riha, Renata L Harris, Sarah E Starr, John M Deary, Ian J Sleep Cognitive, Affective and Behavioral Neuroscience of Sleep We examined associations between self-reported sleep measures and cognitive level and change (age 70–76 years) in a longitudinal, same-year-of-birth cohort study (baseline N = 1091; longitudinal N = 664). We also leveraged GWAS summary data to ascertain whether polygenic scores (PGS) of chronotype and sleep duration related to self-reported sleep, and to cognitive level and change. Shorter sleep latency was associated with significantly higher levels of visuospatial ability, processing speed, and verbal memory (β ≥ |0.184|, SE ≤ 0.075, p ≤ 0.003). Longer daytime sleep duration was significantly associated slower processing speed (β = −0.085, SE = 0.027, p = 0.001), and with steeper 6-year decline in visuospatial reasoning (β = −0.009, SE = 0.003, p = 0.008), and processing speed (β = −0.009, SE = 0.002, p < 0.001). Only longitudinal associations between longer daytime sleeping and steeper cognitive declines survived correction for important health covariates and false discovery rate (FDR). PGS of chronotype and sleep duration were nominally associated with specific self-reported sleep characteristics for most SNP thresholds (standardized β range = |0.123 to 0.082|, p range = 0.003 to 0.046), but neither PGS predicted cognitive level or change following FDR. Daytime sleep duration is a potentially important correlate of cognitive decline in visuospatial reasoning and processing speed in older age, whereas cross-sectional associations are partially confounded by important health factors. A genetic propensity toward morningness and sleep duration were weakly, but consistently, related to self-reported sleep characteristics, and did not relate to cognitive level or change. Oxford University Press 2019-01-21 /pmc/articles/PMC6448287/ /pubmed/30668819 http://dx.doi.org/10.1093/sleep/zsz019 Text en © Sleep Research Society 2019. Published by Oxford University Press [on behalf of the Sleep Research Society]. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cognitive, Affective and Behavioral Neuroscience of Sleep
Cox, Simon R
Ritchie, Stuart J
Allerhand, Mike
Hagenaars, Saskia P
Radakovic, Ratko
Breen, David P
Davies, Gail
Riha, Renata L
Harris, Sarah E
Starr, John M
Deary, Ian J
Sleep and cognitive aging in the eighth decade of life
title Sleep and cognitive aging in the eighth decade of life
title_full Sleep and cognitive aging in the eighth decade of life
title_fullStr Sleep and cognitive aging in the eighth decade of life
title_full_unstemmed Sleep and cognitive aging in the eighth decade of life
title_short Sleep and cognitive aging in the eighth decade of life
title_sort sleep and cognitive aging in the eighth decade of life
topic Cognitive, Affective and Behavioral Neuroscience of Sleep
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448287/
https://www.ncbi.nlm.nih.gov/pubmed/30668819
http://dx.doi.org/10.1093/sleep/zsz019
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