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Spectrum of Thyroid Abnormalities among Children Living with HIV in Lagos, Nigeria

Thyroid disorders have been described in an adult population but are underreported in the pediatric population. The aim of this study was to determine the prevalence and describe the spectrum of thyroid abnormalities among HIV infected children on Highly Active Antiretroviral Therapy (HAART) in Lago...

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Autores principales: Akinsete, Adeseye, Oyenusi, Elizabeth, Odugbemi, Babatunde, Odugbemi, Tinuola, Temiye, Edamisan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448344/
https://www.ncbi.nlm.nih.gov/pubmed/31015954
http://dx.doi.org/10.1155/2019/1096739
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author Akinsete, Adeseye
Oyenusi, Elizabeth
Odugbemi, Babatunde
Odugbemi, Tinuola
Temiye, Edamisan
author_facet Akinsete, Adeseye
Oyenusi, Elizabeth
Odugbemi, Babatunde
Odugbemi, Tinuola
Temiye, Edamisan
author_sort Akinsete, Adeseye
collection PubMed
description Thyroid disorders have been described in an adult population but are underreported in the pediatric population. The aim of this study was to determine the prevalence and describe the spectrum of thyroid abnormalities among HIV infected children on Highly Active Antiretroviral Therapy (HAART) in Lagos, Nigeria. This was a cross-sectional study carried out at a teaching hospital with an antiretroviral therapy (ART) center. Serum levels of thyroid stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4) were analyzed in 83 children living with HIV on HAART and 51 controls. The prevalence of thyroid dysfunction and correlation of fT3, fT4, and TSH with duration on HAART, age, CD4 count, and nutritional status were assessed. Thyroid abnormalities were seen in 9.6% of the children living with HIV comprising subclinical hypothyroidism in 6%, euthyroid sick syndrome in 2.4%, and overt hypothyroidism in 1.2% as compared to 2% subclinical thyroid disease among the controls (p= 0.15). Hypothyroidism was correlated with CD4 count and viral load. None of the patients had clinical features of thyroid disease. Thyroid abnormalities were more prevalent among children living with HIV and yearly screening with follow-up is advocated.
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spelling pubmed-64483442019-04-23 Spectrum of Thyroid Abnormalities among Children Living with HIV in Lagos, Nigeria Akinsete, Adeseye Oyenusi, Elizabeth Odugbemi, Babatunde Odugbemi, Tinuola Temiye, Edamisan J Thyroid Res Research Article Thyroid disorders have been described in an adult population but are underreported in the pediatric population. The aim of this study was to determine the prevalence and describe the spectrum of thyroid abnormalities among HIV infected children on Highly Active Antiretroviral Therapy (HAART) in Lagos, Nigeria. This was a cross-sectional study carried out at a teaching hospital with an antiretroviral therapy (ART) center. Serum levels of thyroid stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4) were analyzed in 83 children living with HIV on HAART and 51 controls. The prevalence of thyroid dysfunction and correlation of fT3, fT4, and TSH with duration on HAART, age, CD4 count, and nutritional status were assessed. Thyroid abnormalities were seen in 9.6% of the children living with HIV comprising subclinical hypothyroidism in 6%, euthyroid sick syndrome in 2.4%, and overt hypothyroidism in 1.2% as compared to 2% subclinical thyroid disease among the controls (p= 0.15). Hypothyroidism was correlated with CD4 count and viral load. None of the patients had clinical features of thyroid disease. Thyroid abnormalities were more prevalent among children living with HIV and yearly screening with follow-up is advocated. Hindawi 2019-03-21 /pmc/articles/PMC6448344/ /pubmed/31015954 http://dx.doi.org/10.1155/2019/1096739 Text en Copyright © 2019 Adeseye Akinsete et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Akinsete, Adeseye
Oyenusi, Elizabeth
Odugbemi, Babatunde
Odugbemi, Tinuola
Temiye, Edamisan
Spectrum of Thyroid Abnormalities among Children Living with HIV in Lagos, Nigeria
title Spectrum of Thyroid Abnormalities among Children Living with HIV in Lagos, Nigeria
title_full Spectrum of Thyroid Abnormalities among Children Living with HIV in Lagos, Nigeria
title_fullStr Spectrum of Thyroid Abnormalities among Children Living with HIV in Lagos, Nigeria
title_full_unstemmed Spectrum of Thyroid Abnormalities among Children Living with HIV in Lagos, Nigeria
title_short Spectrum of Thyroid Abnormalities among Children Living with HIV in Lagos, Nigeria
title_sort spectrum of thyroid abnormalities among children living with hiv in lagos, nigeria
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448344/
https://www.ncbi.nlm.nih.gov/pubmed/31015954
http://dx.doi.org/10.1155/2019/1096739
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