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Fasting insulin, insulin resistance, and risk of cardiovascular or all-cause mortality in non-diabetic adults: a meta-analysis
Studies on elevated fasting insulin or insulin resistance (IR) and cardiovascular or all-cause mortality risk in non-diabetic individuals have yielded conflicting results. This meta-analysis aimed to evaluate the association of elevated fasting insulin levels or IR as defined by homeostasis model as...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448479/ https://www.ncbi.nlm.nih.gov/pubmed/28811358 http://dx.doi.org/10.1042/BSR20170947 |
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author | Zhang, Xiaohong Li, Jun Zheng, Shuiping Luo, Qiuyun Zhou, Chunmei Wang, Chaoyang |
author_facet | Zhang, Xiaohong Li, Jun Zheng, Shuiping Luo, Qiuyun Zhou, Chunmei Wang, Chaoyang |
author_sort | Zhang, Xiaohong |
collection | PubMed |
description | Studies on elevated fasting insulin or insulin resistance (IR) and cardiovascular or all-cause mortality risk in non-diabetic individuals have yielded conflicting results. This meta-analysis aimed to evaluate the association of elevated fasting insulin levels or IR as defined by homeostasis model assessment of IR (HOMA-IR) with cardiovascular or all-cause mortality in non-diabetic adults. We searched for relevant studies in PubMed and Emabse databases until November 2016. Only prospective observational studies investigating the association of elevated fasting insulin levels or HOMA-IR with cardiovascular or all-cause mortality risk in non-diabetic adults were included. Risk ratio (RR) with its 95% confidence intervals (CIs) was pooled for the highest compared with the lowest category of fasting insulin levels or HOMA-IR. Seven articles involving 26976 non-diabetic adults were included. The pooled, adjusted RR of all-cause mortality comparing the highest with the lowest category was 1.13 (95% CI: 1.00–1.27; P=0.058) for fasting insulin levels and 1.34 (95% CI: 1.11–1.62; P=0.002) for HOMA-IR, respectively. When comparing the highest with the lowest category, the pooled adjusted RR of cardiovascular mortality was 2.11 (95% CI: 1.01–4.41; P=0.048) for HOMA-IR in two studies and 1.40 (95% CI: 0.49–3.96; P=0.526) for fasting insulin levels in one study. IR as measured by HOMA-IR but not fasting insulin appears to be independently associated with greater risk of cardiovascular or all-cause mortality in non-diabetic adults. However, the association of fasting insulin and HOMA-IR with cardiovascular mortality may be unreliable due to the small number of articles included. |
format | Online Article Text |
id | pubmed-6448479 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64484792019-04-16 Fasting insulin, insulin resistance, and risk of cardiovascular or all-cause mortality in non-diabetic adults: a meta-analysis Zhang, Xiaohong Li, Jun Zheng, Shuiping Luo, Qiuyun Zhou, Chunmei Wang, Chaoyang Biosci Rep Research Articles Studies on elevated fasting insulin or insulin resistance (IR) and cardiovascular or all-cause mortality risk in non-diabetic individuals have yielded conflicting results. This meta-analysis aimed to evaluate the association of elevated fasting insulin levels or IR as defined by homeostasis model assessment of IR (HOMA-IR) with cardiovascular or all-cause mortality in non-diabetic adults. We searched for relevant studies in PubMed and Emabse databases until November 2016. Only prospective observational studies investigating the association of elevated fasting insulin levels or HOMA-IR with cardiovascular or all-cause mortality risk in non-diabetic adults were included. Risk ratio (RR) with its 95% confidence intervals (CIs) was pooled for the highest compared with the lowest category of fasting insulin levels or HOMA-IR. Seven articles involving 26976 non-diabetic adults were included. The pooled, adjusted RR of all-cause mortality comparing the highest with the lowest category was 1.13 (95% CI: 1.00–1.27; P=0.058) for fasting insulin levels and 1.34 (95% CI: 1.11–1.62; P=0.002) for HOMA-IR, respectively. When comparing the highest with the lowest category, the pooled adjusted RR of cardiovascular mortality was 2.11 (95% CI: 1.01–4.41; P=0.048) for HOMA-IR in two studies and 1.40 (95% CI: 0.49–3.96; P=0.526) for fasting insulin levels in one study. IR as measured by HOMA-IR but not fasting insulin appears to be independently associated with greater risk of cardiovascular or all-cause mortality in non-diabetic adults. However, the association of fasting insulin and HOMA-IR with cardiovascular mortality may be unreliable due to the small number of articles included. Portland Press Ltd. 2017-09-07 /pmc/articles/PMC6448479/ /pubmed/28811358 http://dx.doi.org/10.1042/BSR20170947 Text en © 2017 The Author(s). http://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Articles Zhang, Xiaohong Li, Jun Zheng, Shuiping Luo, Qiuyun Zhou, Chunmei Wang, Chaoyang Fasting insulin, insulin resistance, and risk of cardiovascular or all-cause mortality in non-diabetic adults: a meta-analysis |
title | Fasting insulin, insulin resistance, and risk of cardiovascular or
all-cause mortality in non-diabetic adults: a meta-analysis |
title_full | Fasting insulin, insulin resistance, and risk of cardiovascular or
all-cause mortality in non-diabetic adults: a meta-analysis |
title_fullStr | Fasting insulin, insulin resistance, and risk of cardiovascular or
all-cause mortality in non-diabetic adults: a meta-analysis |
title_full_unstemmed | Fasting insulin, insulin resistance, and risk of cardiovascular or
all-cause mortality in non-diabetic adults: a meta-analysis |
title_short | Fasting insulin, insulin resistance, and risk of cardiovascular or
all-cause mortality in non-diabetic adults: a meta-analysis |
title_sort | fasting insulin, insulin resistance, and risk of cardiovascular or
all-cause mortality in non-diabetic adults: a meta-analysis |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448479/ https://www.ncbi.nlm.nih.gov/pubmed/28811358 http://dx.doi.org/10.1042/BSR20170947 |
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