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De novo NAD(+) synthesis enhances mitochondrial function and improves health

Nicotinamide adenine dinucleotide (NAD(+)) is a cosubstrate for several enzymes, including the sirtuin family of NAD(+)-dependent protein deacylases. Beneficial effects of increased NAD(+) levels and sirtuin activation on mitochondrial homeostasis, organismal metabolism and lifespan have been establ...

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Detalles Bibliográficos
Autores principales:	Katsyuba, Elena, Mottis, Adrienne, Zietak, Marika, De Franco, Francesca, van der Velpen, Vera, Gariani, Karim, Ryu, Dongryeol, Cialabrini, Lucia, Matilainen, Olli, Liscio, Paride, Giacchè, Nicola, Stokar-Regenscheit, Nadine, Legouis, David, de Seigneux, Sophie, Ivanisevic, Julijana, Raffaelli, Nadia, Schoonjans, Kristina, Pellicciari, Roberto, Auwerx, Johan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448761/ https://www.ncbi.nlm.nih.gov/pubmed/30356218 http://dx.doi.org/10.1038/s41586-018-0645-6

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