Baseline Hepatic Levels of miR-29b and Claudin are Respectively Associated with the Stage of Fibrosis and HCV RNA in Hepatitis C

We sought to determine if the baseline hepatic levels of miR-122, miR-29b, Claudin, Occludin, Protein Kinase R (PKR) or PKR activator (PRKRA) were correlated with HCV RNA or stage of fibrosis in patients with chronic hepatitis C (CHC). A total of 25 CHC patients (genotype 1) who were treatment naive...

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Autores principales: Sendi, Hossein, Mehrab-Mohseni, Marjan, Russo, Mark W., Steuerwald, Nury, Jacobs, Carl, Clemens, Mark G., Bonkovsky, Herbert L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448799/
https://www.ncbi.nlm.nih.gov/pubmed/30957098
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author Sendi, Hossein
Mehrab-Mohseni, Marjan
Russo, Mark W.
Steuerwald, Nury
Jacobs, Carl
Clemens, Mark G.
Bonkovsky, Herbert L.
author_facet Sendi, Hossein
Mehrab-Mohseni, Marjan
Russo, Mark W.
Steuerwald, Nury
Jacobs, Carl
Clemens, Mark G.
Bonkovsky, Herbert L.
author_sort Sendi, Hossein
collection PubMed
description We sought to determine if the baseline hepatic levels of miR-122, miR-29b, Claudin, Occludin, Protein Kinase R (PKR) or PKR activator (PRKRA) were correlated with HCV RNA or stage of fibrosis in patients with chronic hepatitis C (CHC). A total of 25 CHC patients (genotype 1) who were treatment naive at the time of sample collection enrolled in this study. By multivariate analysis, CLDN RNA was found as the single independent factor positively correlated with HCV RNA levels (p=0.003), while hepatic miR-29b levels was found as the single independent factor for predicting advanced stage of fibrosis (p=0.028). Conclusion: Our results highlight miR-29b and CLDN as novel predictors of advanced stage of liver fibrosis and baseline HCV RNA in CHC.
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spelling pubmed-64487992019-04-04 Baseline Hepatic Levels of miR-29b and Claudin are Respectively Associated with the Stage of Fibrosis and HCV RNA in Hepatitis C Sendi, Hossein Mehrab-Mohseni, Marjan Russo, Mark W. Steuerwald, Nury Jacobs, Carl Clemens, Mark G. Bonkovsky, Herbert L. Clin Exp Gastroenterol Hepatol Article We sought to determine if the baseline hepatic levels of miR-122, miR-29b, Claudin, Occludin, Protein Kinase R (PKR) or PKR activator (PRKRA) were correlated with HCV RNA or stage of fibrosis in patients with chronic hepatitis C (CHC). A total of 25 CHC patients (genotype 1) who were treatment naive at the time of sample collection enrolled in this study. By multivariate analysis, CLDN RNA was found as the single independent factor positively correlated with HCV RNA levels (p=0.003), while hepatic miR-29b levels was found as the single independent factor for predicting advanced stage of fibrosis (p=0.028). Conclusion: Our results highlight miR-29b and CLDN as novel predictors of advanced stage of liver fibrosis and baseline HCV RNA in CHC. 2019-03-08 2019 /pmc/articles/PMC6448799/ /pubmed/30957098 Text en This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Sendi, Hossein
Mehrab-Mohseni, Marjan
Russo, Mark W.
Steuerwald, Nury
Jacobs, Carl
Clemens, Mark G.
Bonkovsky, Herbert L.
Baseline Hepatic Levels of miR-29b and Claudin are Respectively Associated with the Stage of Fibrosis and HCV RNA in Hepatitis C
title Baseline Hepatic Levels of miR-29b and Claudin are Respectively Associated with the Stage of Fibrosis and HCV RNA in Hepatitis C
title_full Baseline Hepatic Levels of miR-29b and Claudin are Respectively Associated with the Stage of Fibrosis and HCV RNA in Hepatitis C
title_fullStr Baseline Hepatic Levels of miR-29b and Claudin are Respectively Associated with the Stage of Fibrosis and HCV RNA in Hepatitis C
title_full_unstemmed Baseline Hepatic Levels of miR-29b and Claudin are Respectively Associated with the Stage of Fibrosis and HCV RNA in Hepatitis C
title_short Baseline Hepatic Levels of miR-29b and Claudin are Respectively Associated with the Stage of Fibrosis and HCV RNA in Hepatitis C
title_sort baseline hepatic levels of mir-29b and claudin are respectively associated with the stage of fibrosis and hcv rna in hepatitis c
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448799/
https://www.ncbi.nlm.nih.gov/pubmed/30957098
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