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Fetal ocular development in the second trimester of pregnancy documented by 7.0 T postmortem Magnetic Resonance Imaging

Few investigators have analyzed fetal ocular growth with Magnetic Resonance Imaging (MRI) of high magnetic strength. Our purpose is to obtain normative biometrics for fetal ocular development in the second trimester of pregnancy. Sixty specimens with a gestational age (GA) of 12–23 weeks were scanne...

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Autores principales: Zhang, Zhonghe, Lin, Xiangtao, Yu, Qiaowen, Teng, Gaojun, Zang, Fengchao, Wang, Ximing, Liu, Shuwei, Hou, Zhongyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448861/
https://www.ncbi.nlm.nih.gov/pubmed/30947240
http://dx.doi.org/10.1371/journal.pone.0214939
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author Zhang, Zhonghe
Lin, Xiangtao
Yu, Qiaowen
Teng, Gaojun
Zang, Fengchao
Wang, Ximing
Liu, Shuwei
Hou, Zhongyu
author_facet Zhang, Zhonghe
Lin, Xiangtao
Yu, Qiaowen
Teng, Gaojun
Zang, Fengchao
Wang, Ximing
Liu, Shuwei
Hou, Zhongyu
author_sort Zhang, Zhonghe
collection PubMed
description Few investigators have analyzed fetal ocular growth with Magnetic Resonance Imaging (MRI) of high magnetic strength. Our purpose is to obtain normative biometrics for fetal ocular development in the second trimester of pregnancy. Sixty specimens with a gestational age (GA) of 12–23 weeks were scanned using a 7.0 T MRI scanner. The linear interocular and binocular distances (IOD and BOD, respectively), globe diameter (GD) and lens diameter (LD) were measured on the transverse section of the largest diameter of the eyeballs. The three dimensional (3D) visualization model of the eyeball was reconstructed with Amira software. Then, the globe and lens volumes (GV and LV, respectively) were obtained. All the measurements were plotted as a function of GA. The fetal ocular structures in the second trimester of pregnancy could be clearly delineated on 7.0 T postmortem MRI images. All the linear measurements logarithmically increased with GA, while, the volumetric measurements linearly increased with GA. Postmortem MRI of high magnetic strength can clearly document fetal ocular growth in the second trimester of pregnancy. These quantitative data may be a valuable reference for the assessment of normal fetal eyeball development in clinical settings and may be considered a supplement to anatomical investigations.
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spelling pubmed-64488612019-04-19 Fetal ocular development in the second trimester of pregnancy documented by 7.0 T postmortem Magnetic Resonance Imaging Zhang, Zhonghe Lin, Xiangtao Yu, Qiaowen Teng, Gaojun Zang, Fengchao Wang, Ximing Liu, Shuwei Hou, Zhongyu PLoS One Research Article Few investigators have analyzed fetal ocular growth with Magnetic Resonance Imaging (MRI) of high magnetic strength. Our purpose is to obtain normative biometrics for fetal ocular development in the second trimester of pregnancy. Sixty specimens with a gestational age (GA) of 12–23 weeks were scanned using a 7.0 T MRI scanner. The linear interocular and binocular distances (IOD and BOD, respectively), globe diameter (GD) and lens diameter (LD) were measured on the transverse section of the largest diameter of the eyeballs. The three dimensional (3D) visualization model of the eyeball was reconstructed with Amira software. Then, the globe and lens volumes (GV and LV, respectively) were obtained. All the measurements were plotted as a function of GA. The fetal ocular structures in the second trimester of pregnancy could be clearly delineated on 7.0 T postmortem MRI images. All the linear measurements logarithmically increased with GA, while, the volumetric measurements linearly increased with GA. Postmortem MRI of high magnetic strength can clearly document fetal ocular growth in the second trimester of pregnancy. These quantitative data may be a valuable reference for the assessment of normal fetal eyeball development in clinical settings and may be considered a supplement to anatomical investigations. Public Library of Science 2019-04-04 /pmc/articles/PMC6448861/ /pubmed/30947240 http://dx.doi.org/10.1371/journal.pone.0214939 Text en © 2019 Zhang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Zhang, Zhonghe
Lin, Xiangtao
Yu, Qiaowen
Teng, Gaojun
Zang, Fengchao
Wang, Ximing
Liu, Shuwei
Hou, Zhongyu
Fetal ocular development in the second trimester of pregnancy documented by 7.0 T postmortem Magnetic Resonance Imaging
title Fetal ocular development in the second trimester of pregnancy documented by 7.0 T postmortem Magnetic Resonance Imaging
title_full Fetal ocular development in the second trimester of pregnancy documented by 7.0 T postmortem Magnetic Resonance Imaging
title_fullStr Fetal ocular development in the second trimester of pregnancy documented by 7.0 T postmortem Magnetic Resonance Imaging
title_full_unstemmed Fetal ocular development in the second trimester of pregnancy documented by 7.0 T postmortem Magnetic Resonance Imaging
title_short Fetal ocular development in the second trimester of pregnancy documented by 7.0 T postmortem Magnetic Resonance Imaging
title_sort fetal ocular development in the second trimester of pregnancy documented by 7.0 t postmortem magnetic resonance imaging
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448861/
https://www.ncbi.nlm.nih.gov/pubmed/30947240
http://dx.doi.org/10.1371/journal.pone.0214939
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