Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor

AIMS/HYPOTHESIS: Podocytes are insulin-responsive cells of the glomerular filtration barrier and are key in preventing albuminuria, a hallmark feature of diabetic nephropathy. While there is evidence that a loss of insulin signalling to podocytes is detrimental, the molecular mechanisms underpinning...

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Detalles Bibliográficos
Autores principales: Lay, Abigail C., Hurcombe, Jenny A., Betin, Virginie M. S., Barrington, Fern, Rollason, Ruth, Ni, Lan, Gillam, Lawrence, Pearson, Grace M. E., Østergaard, Mette V., Hamidi, Hellyeh, Lennon, Rachel, Welsh, Gavin I., Coward, Richard J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448913/
https://www.ncbi.nlm.nih.gov/pubmed/28852804
http://dx.doi.org/10.1007/s00125-017-4394-0

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