Cargando…

Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetes

AIMS/HYPOTHESIS: Microvascular complications in the heart and kidney are strongly associated with an overall rise in inflammation. Annexin A1 (ANXA1) is an endogenous anti-inflammatory molecule that limits and resolves inflammation. In this study, we have used a bedside to bench approach to investig...

Descripción completa

Detalles Bibliográficos
Autores principales:	Purvis, Gareth S. D., Chiazza, Fausto, Chen, Jianmin, Azevedo-Loiola, Rodrigo, Martin, Lukas, Kusters, Dennis H. M., Reutelingsperger, Chris, Fountoulakis, Nikolaos, Gnudi, Luigi, Yaqoob, Muhammed M., Collino, Massimo, Thiemermann, Christoph, Solito, Egle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448955/ https://www.ncbi.nlm.nih.gov/pubmed/29085990 http://dx.doi.org/10.1007/s00125-017-4469-y

Ejemplares similares

Annexin-A1: Therapeutic Potential in Microvascular Disease
por: Purvis, Gareth S. D., et al.
Publicado: (2019)

Identification of AnnexinA1 as an Endogenous Regulator of RhoA, and Its Role in the Pathophysiology and Experimental Therapy of Type-2 Diabetes
por: Purvis, Gareth S. D., et al.
Publicado: (2019)

The restorative role of annexin A1 at the blood–brain barrier
por: McArthur, Simon, et al.
Publicado: (2016)

Estrogen Promotes Pro-resolving Microglial Behavior and Phagocytic Cell Clearance Through the Actions of Annexin A1
por: Loiola, Rodrigo Azevedo, et al.
Publicado: (2019)

Inhibition of IκB Kinase at 24 Hours After Acute Kidney Injury Improves Recovery of Renal Function and Attenuates Fibrosis
por: Johnson, Florence L., et al.
Publicado: (2017)

The anti-inflammatory Annexin A1 induces the clearance and degradation of the amyloid-β peptide
por: Ries, Miriam, et al.
Publicado: (2016)

Annexin A1: Uncovering the Many Talents of an Old Protein
por: Sheikh, Madeeha H., et al.
Publicado: (2018)

Linagliptin Attenuates the Cardiac Dysfunction Associated With Experimental Sepsis in Mice With Pre-existing Type 2 Diabetes by Inhibiting NF-κB
por: Al Zoubi, Sura, et al.
Publicado: (2018)

Gender Dimorphism of the Cardiac Dysfunction in Murine Sepsis: Signalling Mechanisms and Age-Dependency
por: Chen, Jianmin, et al.
Publicado: (2014)

Annexin A1 restores cerebrovascular integrity concomitant with reduced amyloid-β and tau pathology
por: Ries, Miriam, et al.
Publicado: (2021)

Bruton's Tyrosine Kinase Inhibition Attenuates the Cardiac Dysfunction Caused by Cecal Ligation and Puncture in Mice
por: O'Riordan, Caroline E., et al.
Publicado: (2019)

‘Preconditioning’ with Low Dose Lipopolysaccharide Aggravates the Organ Injury / Dysfunction Caused by Hemorrhagic Shock in Rats
por: Sordi, Regina, et al.
Publicado: (2015)

Inhibition of Bruton's TK regulates macrophage NF‐κB and NLRP3 inflammasome activation in metabolic inflammation
por: Purvis, Gareth S.D., et al.
Publicado: (2020)

Relationship between HPV and the biomarkers annexin A1 and p53 in oropharyngeal cancer
por: Queiroz, Cleberson Jean dos Santos, et al.
Publicado: (2014)

Annexin A1/Formyl Peptide Receptor Pathway Controls Uterine Receptivity to the Blastocyst
por: Hebeda, Cristina B., et al.
Publicado: (2020)

Anti-Allergic Cromones Inhibit Histamine and Eicosanoid Release from Activated Human and Murine Mast Cells by Releasing Annexin A1
por: Yazid, Samia, et al.
Publicado: (2013)

The role of the Annexin-A1/FPR2 system in the regulation of mast cell degranulation provoked by compound 48/80 and in the inhibitory action of nedocromil
por: Sinniah, Ajantha, et al.
Publicado: (2016)

Annexin A1 attenuates cardiac diastolic dysfunction in mice with inflammatory arthritis
por: Chen, Jianmin, et al.
Publicado: (2021)

RvE1 Attenuates Polymicrobial Sepsis-Induced Cardiac Dysfunction and Enhances Bacterial Clearance
por: Chen, Jianmin, et al.
Publicado: (2020)

Molecular Imaging of Cell Death in Tumors. Increasing Annexin A5 Size Reduces Contribution of Phosphatidylserine-Targeting Function to Tumor Uptake
por: Ungethüm, Lisette, et al.
Publicado: (2014)

The synthetic antimicrobial peptide 19-2.5 attenuates septic cardiomyopathy and prevents down-regulation of SERCA2 in polymicrobial sepsis
por: Martin, Lukas, et al.
Publicado: (2016)

Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice
por: Locatelli, Irene, et al.
Publicado: (2014)

A Synthetic Peptide Designed to Neutralize Lipopolysaccharides Attenuates Metaflammation and Diet-Induced Metabolic Derangements in Mice
por: Mohammad, Shireen, et al.
Publicado: (2021)

Erythropoietin in the intensive care unit: beyond treatment of anemia
por: Patel, Nimesh SA, et al.
Publicado: (2011)

Baricitinib counteracts metaflammation, thus protecting against diet-induced metabolic abnormalities in mice
por: Collotta, Debora, et al.
Publicado: (2020)

The NLRP3 Inflammasome as a Novel Player of the Intercellular Crosstalk in Metabolic Disorders
por: Benetti, Elisa, et al.
Publicado: (2013)

Pharmacological Treatment with Annexin A1 Reduces Atherosclerotic Plaque Burden in LDLR(-/-) Mice on Western Type Diet
por: Kusters, Dennis H. M., et al.
Publicado: (2015)

Scavenging Circulating Mitochondrial DNA as a Potential Therapeutic Option for Multiple Organ Dysfunction in Trauma Hemorrhage
por: Aswani, Andrew, et al.
Publicado: (2018)

The effect of DPP-4 inhibition to improve functional outcome after stroke is mediated by the SDF-1α/CXCR4 pathway
por: Chiazza, Fausto, et al.
Publicado: (2018)

Annexin A1 Is Associated with Adverse Clinical Outcomes in Patients with COVID-19
por: Busch, Matthias H., et al.
Publicado: (2022)

Erythropoietin attenuates cardiac dysfunction in experimental sepsis in mice via activation of the β-common receptor
por: Khan, Areeg I., et al.
Publicado: (2013)

Role of Annexin A1 Secreted by Neutrophils in Melanoma Metastasis
por: Sandri, Silvana, et al.
Publicado: (2023)

Perturbations of the anti-ageing hormone Klotho in patients with type 1 diabetes and microalbuminuria
por: Maltese, Giuseppe, et al.
Publicado: (2017)

Dopexamine can attenuate the inflammatory response and protect against organ injury in the absence of significant effects on hemodynamics or regional microvascular flow
por: Bangash, Mansoor N, et al.
Publicado: (2013)

Formyl Peptide Receptors and Annexin A1: Complementary Mechanisms to Infliximab in Murine Experimental Colitis and Crohn’s Disease
por: de Paula-Silva, Marina, et al.
Publicado: (2021)

AnnexinA5-pHrodo: a new molecular probe for measuring efferocytosis
por: Stöhr, R., et al.
Publicado: (2018)

Annexin A5 reduces early plaque formation in ApoE -/- mice
por: Stöhr, Robert, et al.
Publicado: (2017)

Annexin A1 drives macrophage skewing to accelerate muscle regeneration through AMPK activation
por: McArthur, Simon, et al.
Publicado: (2020)

Induction of annexin-1 at transcriptional and post-transcriptional level in rat brain by methylprednisolone and the 21-aminosteroid U74389F
por: Voermans, P. H., et al.
Publicado: (1996)

(99m)Tc-HYNIC-Annexin A5 in Oncology: Evaluating Efficacy of Anti-Cancer Therapies
por: Schaper, Frédéric L.W.V.J., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_5lr2dmah7ftqpu0ajf4e1isnqq