Cargando…
The association between Helicobacter pylori seropositivity and risk of new-onset diabetes: a prospective cohort study
AIMS/HYPOTHESIS: Previous studies have suggested a possible connection between Helicobacter pylori (H. pylori) infection and diabetes risk. However, prospective studies examining direct associations between these two factors are relatively lacking. In this prospective cohort study, we aimed to evalu...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448956/ https://www.ncbi.nlm.nih.gov/pubmed/29085991 http://dx.doi.org/10.1007/s00125-017-4465-2 |
_version_ | 1783408764020326400 |
---|---|
author | Zhou, Mengge Liu, Jing Qi, Yue Wang, Miao Wang, Ying Zhao, Fan Hao, Yongchen Zhao, Dong |
author_facet | Zhou, Mengge Liu, Jing Qi, Yue Wang, Miao Wang, Ying Zhao, Fan Hao, Yongchen Zhao, Dong |
author_sort | Zhou, Mengge |
collection | PubMed |
description | AIMS/HYPOTHESIS: Previous studies have suggested a possible connection between Helicobacter pylori (H. pylori) infection and diabetes risk. However, prospective studies examining direct associations between these two factors are relatively lacking. In this prospective cohort study, we aimed to evaluate the association between H. pylori infection and risk of developing diabetes. METHODS: We performed a population-based prospective study, recruiting participants aged 45–74 years and without diabetes from the Chinese Multi-provincial Cohort Study in 2002, with a 10 year follow-up to investigate development of diabetes. H. pylori serostatus was determined by measuring serum H. pylori antibodies. H. pylori seropositivity was defined as the antibody concentration ≥ 10 U/ml. To examine the association between H. pylori seropositivity and diabetes risk, modified Poisson regression was performed. RESULTS: Of 2085 participants without diabetes, 1208 (57.9%) were H. pylori seropositive in 2002. After multivariate adjustment of possible diabetes risk factors, H. pylori seropositivity was associated with lower risk of diabetes (RR 0.78 [95% CI 0.63, 0.97], p = 0.022). Of the 1275 participants with H. pylori antibody measurements in both 2002 and 2007, 677 (53.1%) were persistently seropositive. A lower risk of diabetes was also observed in participants with persistent H. pylori seropositivity (RR 0.61 [95% CI 0.41, 0.93], p = 0.020), compared with those persistently seronegative. CONCLUSIONS/INTERPRETATION: H. pylori seropositivity was associated with lower risk of diabetes in this prospective cohort study. Extrapolation of these results and the mechanism underlying the observed association require further investigation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00125-017-4465-2) contains peer-reviewed but unedited supplementary material, which is available to authorised users. |
format | Online Article Text |
id | pubmed-6448956 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-64489562019-04-17 The association between Helicobacter pylori seropositivity and risk of new-onset diabetes: a prospective cohort study Zhou, Mengge Liu, Jing Qi, Yue Wang, Miao Wang, Ying Zhao, Fan Hao, Yongchen Zhao, Dong Diabetologia Article AIMS/HYPOTHESIS: Previous studies have suggested a possible connection between Helicobacter pylori (H. pylori) infection and diabetes risk. However, prospective studies examining direct associations between these two factors are relatively lacking. In this prospective cohort study, we aimed to evaluate the association between H. pylori infection and risk of developing diabetes. METHODS: We performed a population-based prospective study, recruiting participants aged 45–74 years and without diabetes from the Chinese Multi-provincial Cohort Study in 2002, with a 10 year follow-up to investigate development of diabetes. H. pylori serostatus was determined by measuring serum H. pylori antibodies. H. pylori seropositivity was defined as the antibody concentration ≥ 10 U/ml. To examine the association between H. pylori seropositivity and diabetes risk, modified Poisson regression was performed. RESULTS: Of 2085 participants without diabetes, 1208 (57.9%) were H. pylori seropositive in 2002. After multivariate adjustment of possible diabetes risk factors, H. pylori seropositivity was associated with lower risk of diabetes (RR 0.78 [95% CI 0.63, 0.97], p = 0.022). Of the 1275 participants with H. pylori antibody measurements in both 2002 and 2007, 677 (53.1%) were persistently seropositive. A lower risk of diabetes was also observed in participants with persistent H. pylori seropositivity (RR 0.61 [95% CI 0.41, 0.93], p = 0.020), compared with those persistently seronegative. CONCLUSIONS/INTERPRETATION: H. pylori seropositivity was associated with lower risk of diabetes in this prospective cohort study. Extrapolation of these results and the mechanism underlying the observed association require further investigation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00125-017-4465-2) contains peer-reviewed but unedited supplementary material, which is available to authorised users. Springer Berlin Heidelberg 2017-10-30 2018 /pmc/articles/PMC6448956/ /pubmed/29085991 http://dx.doi.org/10.1007/s00125-017-4465-2 Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Article Zhou, Mengge Liu, Jing Qi, Yue Wang, Miao Wang, Ying Zhao, Fan Hao, Yongchen Zhao, Dong The association between Helicobacter pylori seropositivity and risk of new-onset diabetes: a prospective cohort study |
title | The association between Helicobacter pylori seropositivity and risk of new-onset diabetes: a prospective cohort study |
title_full | The association between Helicobacter pylori seropositivity and risk of new-onset diabetes: a prospective cohort study |
title_fullStr | The association between Helicobacter pylori seropositivity and risk of new-onset diabetes: a prospective cohort study |
title_full_unstemmed | The association between Helicobacter pylori seropositivity and risk of new-onset diabetes: a prospective cohort study |
title_short | The association between Helicobacter pylori seropositivity and risk of new-onset diabetes: a prospective cohort study |
title_sort | association between helicobacter pylori seropositivity and risk of new-onset diabetes: a prospective cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448956/ https://www.ncbi.nlm.nih.gov/pubmed/29085991 http://dx.doi.org/10.1007/s00125-017-4465-2 |
work_keys_str_mv | AT zhoumengge theassociationbetweenhelicobacterpyloriseropositivityandriskofnewonsetdiabetesaprospectivecohortstudy AT liujing theassociationbetweenhelicobacterpyloriseropositivityandriskofnewonsetdiabetesaprospectivecohortstudy AT qiyue theassociationbetweenhelicobacterpyloriseropositivityandriskofnewonsetdiabetesaprospectivecohortstudy AT wangmiao theassociationbetweenhelicobacterpyloriseropositivityandriskofnewonsetdiabetesaprospectivecohortstudy AT wangying theassociationbetweenhelicobacterpyloriseropositivityandriskofnewonsetdiabetesaprospectivecohortstudy AT zhaofan theassociationbetweenhelicobacterpyloriseropositivityandriskofnewonsetdiabetesaprospectivecohortstudy AT haoyongchen theassociationbetweenhelicobacterpyloriseropositivityandriskofnewonsetdiabetesaprospectivecohortstudy AT zhaodong theassociationbetweenhelicobacterpyloriseropositivityandriskofnewonsetdiabetesaprospectivecohortstudy AT zhoumengge associationbetweenhelicobacterpyloriseropositivityandriskofnewonsetdiabetesaprospectivecohortstudy AT liujing associationbetweenhelicobacterpyloriseropositivityandriskofnewonsetdiabetesaprospectivecohortstudy AT qiyue associationbetweenhelicobacterpyloriseropositivityandriskofnewonsetdiabetesaprospectivecohortstudy AT wangmiao associationbetweenhelicobacterpyloriseropositivityandriskofnewonsetdiabetesaprospectivecohortstudy AT wangying associationbetweenhelicobacterpyloriseropositivityandriskofnewonsetdiabetesaprospectivecohortstudy AT zhaofan associationbetweenhelicobacterpyloriseropositivityandriskofnewonsetdiabetesaprospectivecohortstudy AT haoyongchen associationbetweenhelicobacterpyloriseropositivityandriskofnewonsetdiabetesaprospectivecohortstudy AT zhaodong associationbetweenhelicobacterpyloriseropositivityandriskofnewonsetdiabetesaprospectivecohortstudy |