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Refractoriness to transarterial chemoembolization in patients with recurrent hepatocellular carcinoma after curative resection

BACKGROUND/AIMS: It is important to identify patients who are refractory to transarterial chemoembolization (TACE), which is performed for the treatment of hepatocellular carcinoma (HCC). We investigated the predictors of poor treatment outcomes in patients with recurrent HCC treated who were treate...

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Autores principales: Jeon, Mi Young, Kim, Hye Soo, Lim, Tae Seop, Han, Dai Hoon, Kim, Beom Kyung, Park, Jun Yong, Kim, Do Young, Ahn, Sang Hoon, Choi, Gi Hong, Choi, Jin Sub, Han, Kwang-Hyub, Kim, Seung Up
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449032/
https://www.ncbi.nlm.nih.gov/pubmed/30947275
http://dx.doi.org/10.1371/journal.pone.0214613
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author Jeon, Mi Young
Kim, Hye Soo
Lim, Tae Seop
Han, Dai Hoon
Kim, Beom Kyung
Park, Jun Yong
Kim, Do Young
Ahn, Sang Hoon
Choi, Gi Hong
Choi, Jin Sub
Han, Kwang-Hyub
Kim, Seung Up
author_facet Jeon, Mi Young
Kim, Hye Soo
Lim, Tae Seop
Han, Dai Hoon
Kim, Beom Kyung
Park, Jun Yong
Kim, Do Young
Ahn, Sang Hoon
Choi, Gi Hong
Choi, Jin Sub
Han, Kwang-Hyub
Kim, Seung Up
author_sort Jeon, Mi Young
collection PubMed
description BACKGROUND/AIMS: It is important to identify patients who are refractory to transarterial chemoembolization (TACE), which is performed for the treatment of hepatocellular carcinoma (HCC). We investigated the predictors of poor treatment outcomes in patients with recurrent HCC treated who were treated with TACE after curative resection. METHODS: 428 patients with recurrent HCC after curative resection who were treated with TACE were enrolled. RESULTS: The median age of the study population was 59.2 years. On multivariate analysis, ≥2 TACE procedures within 6 months (hazard ratio [HR] = 1.898), and the des-gamma carboxyprothrombin level (HR = 1.000) independently predicted the progression to Barcelona Clinic Liver Cancer (BCLC) stage C in patients with BCLC stage 0-B HCC (both P<0.05). In addition, ≥2 and ≥3 TACE procedures within 6 months independently predicted mortality in the entire study population (HR = 1.863 and 1.620, respectively). The probability of progression to BCLC stage C in patients with BCLC stage 0-B HCC and the mortality rate in the entire study population were significantly higher in patients treated with ≥2 TACE within 6 months than in those who underwent fewer procedures (P = 0.002 and P<0.001, respectively). CONCLUSIONS: More than 2 TACE procedures within 6 months might be associated with the refractoriness to TACE in patients with recurrent HCC after curative resection.
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spelling pubmed-64490322019-04-19 Refractoriness to transarterial chemoembolization in patients with recurrent hepatocellular carcinoma after curative resection Jeon, Mi Young Kim, Hye Soo Lim, Tae Seop Han, Dai Hoon Kim, Beom Kyung Park, Jun Yong Kim, Do Young Ahn, Sang Hoon Choi, Gi Hong Choi, Jin Sub Han, Kwang-Hyub Kim, Seung Up PLoS One Research Article BACKGROUND/AIMS: It is important to identify patients who are refractory to transarterial chemoembolization (TACE), which is performed for the treatment of hepatocellular carcinoma (HCC). We investigated the predictors of poor treatment outcomes in patients with recurrent HCC treated who were treated with TACE after curative resection. METHODS: 428 patients with recurrent HCC after curative resection who were treated with TACE were enrolled. RESULTS: The median age of the study population was 59.2 years. On multivariate analysis, ≥2 TACE procedures within 6 months (hazard ratio [HR] = 1.898), and the des-gamma carboxyprothrombin level (HR = 1.000) independently predicted the progression to Barcelona Clinic Liver Cancer (BCLC) stage C in patients with BCLC stage 0-B HCC (both P<0.05). In addition, ≥2 and ≥3 TACE procedures within 6 months independently predicted mortality in the entire study population (HR = 1.863 and 1.620, respectively). The probability of progression to BCLC stage C in patients with BCLC stage 0-B HCC and the mortality rate in the entire study population were significantly higher in patients treated with ≥2 TACE within 6 months than in those who underwent fewer procedures (P = 0.002 and P<0.001, respectively). CONCLUSIONS: More than 2 TACE procedures within 6 months might be associated with the refractoriness to TACE in patients with recurrent HCC after curative resection. Public Library of Science 2019-04-04 /pmc/articles/PMC6449032/ /pubmed/30947275 http://dx.doi.org/10.1371/journal.pone.0214613 Text en © 2019 Jeon et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Jeon, Mi Young
Kim, Hye Soo
Lim, Tae Seop
Han, Dai Hoon
Kim, Beom Kyung
Park, Jun Yong
Kim, Do Young
Ahn, Sang Hoon
Choi, Gi Hong
Choi, Jin Sub
Han, Kwang-Hyub
Kim, Seung Up
Refractoriness to transarterial chemoembolization in patients with recurrent hepatocellular carcinoma after curative resection
title Refractoriness to transarterial chemoembolization in patients with recurrent hepatocellular carcinoma after curative resection
title_full Refractoriness to transarterial chemoembolization in patients with recurrent hepatocellular carcinoma after curative resection
title_fullStr Refractoriness to transarterial chemoembolization in patients with recurrent hepatocellular carcinoma after curative resection
title_full_unstemmed Refractoriness to transarterial chemoembolization in patients with recurrent hepatocellular carcinoma after curative resection
title_short Refractoriness to transarterial chemoembolization in patients with recurrent hepatocellular carcinoma after curative resection
title_sort refractoriness to transarterial chemoembolization in patients with recurrent hepatocellular carcinoma after curative resection
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449032/
https://www.ncbi.nlm.nih.gov/pubmed/30947275
http://dx.doi.org/10.1371/journal.pone.0214613
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