Transcriptome Characterization of Matched Primary Breast and Brain Metastatic Tumors to Detect Novel Actionable Targets

BACKGROUND: Breast cancer brain metastases (BrMs) are defined by complex adaptations to both adjuvant treatment regimens and the brain microenvironment. Consequences of these alterations remain poorly understood, as does their potential for clinical targeting. We utilized genome-wide molecular profi...

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Detalles Bibliográficos
Autores principales: Varešlija, Damir, Priedigkeit, Nolan, Fagan, Ailís, Purcell, Siobhan, Cosgrove, Nicola, O’Halloran, Philip J, Ward, Elspeth, Cocchiglia, Sinéad, Hartmaier, Ryan, Castro, Carlos A, Zhu, Li, Tseng, George C, Lucas, Peter C, Puhalla, Shannon L, Brufsky, Adam M, Hamilton, Ronald L, Mathew, Aju, Leone, Jose P, Basudan, Ahmed, Hudson, Lance, Dwyer, Róisín, Das, Sudipto, O’Connor, Darran P, Buckley, Patrick G, Farrell, Michael, Hill, Arnold D K, Oesterreich, Steffi, Lee, Adrian V, Young, Leonie S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449168/
https://www.ncbi.nlm.nih.gov/pubmed/29961873
http://dx.doi.org/10.1093/jnci/djy110

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