Cargando…

A Plasma-Derived Protein-Metabolite Multiplexed Panel for Early-Stage Pancreatic Cancer

BACKGROUND: We applied a training and testing approach to develop and validate a plasma metabolite panel for the detection of early-stage pancreatic ductal adenocarcinoma (PDAC) alone and in combination with a previously validated protein panel for early-stage PDAC. METHODS: A comprehensive metabolo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fahrmann, Johannes F, Bantis, Leonidas E, Capello, Michela, Scelo, Ghislaine, Dennison, Jennifer B, Patel, Nikul, Murage, Eunice, Vykoukal, Jody, Kundnani, Deepali L, Foretova, Lenka, Fabianova, Eleonora, Holcatova, Ivana, Janout, Vladimir, Feng, Ziding, Yip-Schneider, Michele, Zhang, Jianjun, Brand, Randall, Taguchi, Ayumu, Maitra, Anirban, Brennan, Paul, Max Schmidt, C, Hanash, Samir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449169/ https://www.ncbi.nlm.nih.gov/pubmed/30137376 http://dx.doi.org/10.1093/jnci/djy126

Ejemplares similares

Exosomes harbor B cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicity
por: Capello, Michela, et al.
Publicado: (2019)

Plasma-Derived Extracellular Vesicles Convey Protein Signatures That Reflect Pathophysiology in Lung and Pancreatic Adenocarcinomas
por: Fahrmann, Johannes F., et al.
Publicado: (2020)

Contributions of Circulating microRNAs for Early Detection of Lung Cancer
por: Vykoukal, Jody, et al.
Publicado: (2022)

Extracellular Vesicles Mediate B Cell Immune Response and Are a Potential Target for Cancer Therapy
por: Kato, Taketo, et al.
Publicado: (2020)

Extracellular Vesicles in Lung Cancer: Prospects for Diagnostic and Therapeutic Applications
por: Kato, Taketo, et al.
Publicado: (2021)

Plasma-derived extracellular vesicle proteins as a source of biomarkers for lung adenocarcinoma
por: Vykoukal, Jody, et al.
Publicado: (2017)

A MYC-Driven Plasma Polyamine Signature for Early Detection of Ovarian Cancer
por: Fahrmann, Johannes F., et al.
Publicado: (2021)

c-MYC-Driven Polyamine Metabolism in Ovarian Cancer: From Pathogenesis to Early Detection and Therapy
por: Chen, Yihui, et al.
Publicado: (2023)

A Comprehensive Search of Non-Canonical Proteins in Non-Small Cell Lung Cancer and Their Impact on the Immune Response
por: Irajizad, Ehsan, et al.
Publicado: (2022)

Circulating tumour-derived KRAS mutations in pancreatic cancer cases are predominantly carried by very short fragments of cell-free DNA
por: Zvereva, Maria, et al.
Publicado: (2020)

KRAS mutations in blood circulating cell-free DNA: a pancreatic cancer case-control
por: Le Calvez-Kelm, Florence, et al.
Publicado: (2016)

Mutational Activation of the NRF2 Pathway Upregulates Kynureninase Resulting in Tumor Immunosuppression and Poor Outcome in Lung Adenocarcinoma
por: Fahrmann, Johannes F., et al.
Publicado: (2022)

Integrative Genome-Wide Gene Expression Profiling of Clear Cell Renal Cell Carcinoma in Czech Republic and in the United States
por: Wozniak, Magdalena B., et al.
Publicado: (2013)

Plasma Based Protein Signatures Associated with Small Cell Lung Cancer
por: Fahrmann, Johannes F., et al.
Publicado: (2021)

The kynurenine pathway presents multi-faceted metabolic vulnerabilities in cancer
por: León-Letelier, Ricardo A., et al.
Publicado: (2023)

A blood-based metabolomic signature predictive of risk for pancreatic cancer
por: Irajizad, Ehsan, et al.
Publicado: (2023)

Quantitative imaging to evaluate malignant potential of IPMNs
por: Hanania, Alexander N., et al.
Publicado: (2016)

Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer
por: Vykoukal, Jody, et al.
Publicado: (2020)

Protein citrullination as a source of cancer neoantigens
por: Katayama, Hiroyuki, et al.
Publicado: (2021)

Amino Acid Oncometabolism and Immunomodulation of the Tumor Microenvironment in Lung Cancer
por: Fahrmann, Johannes F., et al.
Publicado: (2020)

CES2 sustains HNF4α expression to promote pancreatic adenocarcinoma progression through an epoxide hydrolase-dependent regulatory loop
por: Chen, Yihui, et al.
Publicado: (2021)

Kynureninase Upregulation Is a Prominent Feature of NFR2-Activated Cancers and Is Associated with Tumor Immunosuppression and Poor Prognosis
por: León-Letelier, Ricardo A., et al.
Publicado: (2023)

Application of Artificial Intelligence to Plasma Metabolomics Profiles to Predict Response to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer
por: Irajizad, Ehsan, et al.
Publicado: (2022)

Circulating Concentrations of Vitamin B6 and Kidney Cancer Prognosis: A Prospective Case-Cohort Study
por: Muller, David C., et al.
Publicado: (2015)

Novel UHRF1-MYC Axis in Acute Lymphoblastic Leukemia
por: Park, Soyoung, et al.
Publicado: (2022)

Proteome Profiling Uncovers an Autoimmune Response Signature That Reflects Ovarian Cancer Pathogenesis
por: Kobayashi, Makoto, et al.
Publicado: (2020)

Morphological findings in frozen non-neoplastic kidney tissues of patients with kidney cancer from large-scale multicentric studies on renal cancer
por: Abedi-Ardekani, Behnoush, et al.
Publicado: (2021)

Survival and prognostic factors of early‐stage non‐small cell lung cancer in Central and Eastern Europe: A prospective cohort study
por: Sheikh, Mahdi, et al.
Publicado: (2023)

Switching Roles of TGF-β in Cancer Development: Implications for Therapeutic Target and Biomarker Studies
por: Sun, Nan, et al.
Publicado: (2016)

Loss of chromosome Y leads to down regulation of KDM5D and KDM6C epigenetic modifiers in clear cell renal cell carcinoma
por: Arseneault, Madeleine, et al.
Publicado: (2017)

Sexual dimorphism in cancer: insights from transcriptional signatures in kidney tissue and renal cell carcinoma
por: Laskar, Ruhina S, et al.
Publicado: (2021)

NFATc Acts as a Non-Canonical Phenotypic Stability Factor for a Hybrid Epithelial/Mesenchymal Phenotype
por: Subbalakshmi, Ayalur Raghu, et al.
Publicado: (2020)

Needlestack: an ultra-sensitive variant caller for multi-sample next generation sequencing data
por: Delhomme, Tiffany M, et al.
Publicado: (2020)

Gene Co-Expression Analysis of Human RNASEH2A Reveals Functional Networks Associated with DNA Replication, DNA Damage Response, and Cell Cycle Regulation
por: Marsili, Stefania, et al.
Publicado: (2021)

Prognostic and Functional Significance of MAP4K5 in Pancreatic Cancer
por: Wang, Oliver H., et al.
Publicado: (2016)

Tobacco smoking, body mass index, hypertension, and kidney cancer risk in central and eastern Europe
por: Brennan, P, et al.
Publicado: (2008)

Genetic Contributions to The Association Between Adult Height and Head and Neck Cancer: A Mendelian Randomization Analysis
por: Pastorino, Roberta, et al.
Publicado: (2018)

PSAT380 Characteristics and prognosis of Differentiated Thyroid Cancer in patients with Graves Disease
por: Panthi, Sujata, et al.
Publicado: (2022)

Comprehensive Proteomic Profiling of Aldehyde Dehydrogenases in Lung Adenocarcinoma Cell Lines
por: Zhang, Qing, et al.
Publicado: (2011)

Components of one-carbon metabolism and renal cell carcinoma: a systematic review and meta-analysis
por: Clasen, Joanna L., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ddgu85edg0geul9l31c93qf8om