Cargando…

Influence of Multidrug Resistance-Associated Proteins on the Excretion of the ABCC1 Imaging Probe 6-Bromo-7-[(11)C]Methylpurine in Mice

PURPOSE: Multidrug resistance-associated proteins (MRPs) mediate the hepatobiliary and renal excretion of many drugs and drug conjugates. The positron emission tomography (PET) tracer 6-bromo-7-[(11)C]methylpurine is rapidly converted in tissues by glutathione-S-transferases into its glutathione con...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zoufal, Viktoria, Mairinger, Severin, Krohn, Markus, Wanek, Thomas, Filip, Thomas, Sauberer, Michael, Stanek, Johann, Traxl, Alexander, Schuetz, John D., Kuntner, Claudia, Pahnke, Jens, Langer, Oliver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449286/ https://www.ncbi.nlm.nih.gov/pubmed/29942989 http://dx.doi.org/10.1007/s11307-018-1230-y

Ejemplares similares

Assessing the Functional Redundancy between P-gp and BCRP in Controlling the Brain Distribution and Biliary Excretion of Dual Substrates with PET Imaging in Mice
por: Hernández-Lozano, Irene, et al.
Publicado: (2021)

Brain Distribution of Dual ABCB1/ABCG2 Substrates Is Unaltered in a Beta-Amyloidosis Mouse Model
por: Wanek, Thomas, et al.
Publicado: (2020)

Factors Governing P-Glycoprotein-Mediated Drug–Drug Interactions at the Blood–Brain Barrier Measured with Positron Emission Tomography
por: Wanek, Thomas, et al.
Publicado: (2015)

Use of PET Imaging to Assess the Efficacy of Thiethylperazine to Stimulate Cerebral MRP1 Transport Activity in Wild-Type and APP/PS1-21 Mice
por: Wölfl-Duchek, Michael, et al.
Publicado: (2022)

Characterization of an APP/tau rat model of Alzheimer’s disease by positron emission tomography and immunofluorescent labeling
por: Filip, Thomas, et al.
Publicado: (2021)

Influence of Cation Transporters (OCTs and MATEs) on the Renal and Hepatobiliary Disposition of [(11)C]Metoclopramide in Mice
por: Hernández-Lozano, Irene, et al.
Publicado: (2021)

Inhibition of breast cancer resistance protein at the murine blood-brain barrier by Ko143 studied with [(11)C]tariquidar and PET
por: Wanek, Thomas, et al.
Publicado: (2011)

Small-animal PET evaluation of [(11)C]MC113 as a PET tracer for P-glycoprotein
por: Mairinger, Severin, et al.
Publicado: (2010)

Development and performance test of an online blood sampling system for determination of the arterial input function in rats
por: Roehrbacher, Friedrich, et al.
Publicado: (2015)

Comparison of fully-automated radiosyntheses of [(11)C]erlotinib for preclinical and clinical use starting from in target produced [(11)C]CO(2) or [(11)C]CH(4)
por: Philippe, Cécile, et al.
Publicado: (2018)

Resistance to 6-Methylpurine is Conferred by Defective Adenine Phosphoribosyltransferase in Tetrahymena
por: Akematsu, Takahiko, et al.
Publicado: (2018)

In vivo characterization of [(18)F]AVT-011 as a radiotracer for PET imaging of multidrug resistance
por: Kannan, Pavitra, et al.
Publicado: (2019)

Development of an Effective 6-Methylpurine Counterselection Marker for Genetic Manipulation in Thermococcus barophilus
por: Birien, Tiphaine, et al.
Publicado: (2018)

Aberrant Expression of N-Methylpurine-DNA Glycosylase Influences Patient Survival in Malignant Gliomas
por: Liu, Ce, et al.
Publicado: (2012)

Involvement of N-methylpurine DNA glycosylase in resistance to temozolomide in patient-derived glioma cells
por: Serrano-Heras, Gemma, et al.
Publicado: (2020)

Humanization of the Blood–Brain Barrier Transporter ABCB1 in Mice Disrupts Genomic Locus — Lessons from Three Unsuccessful Approaches
por: Krohn, Markus, et al.
Publicado: (2018)

N-Methylpurine DNA Glycosylase and OGG1 DNA Repair Activities: Opposite Associations With Lung Cancer Risk
por: Leitner-Dagan, Yael, et al.
Publicado: (2012)

Improved Synthesis of β-D-6-Methylpurine Riboside and Antitumor Effects of the β-D- and α-D-Anomers
por: Marasco, Canio J., et al.
Publicado: (2005)

Cross‐Isotopic Bioorthogonal Tools as Molecular Twins for Radiotheranostic Applications
por: Rosecker, Veronika, et al.
Publicado: (2019)

N-methylpurine DNA glycosylase overexpression increases alkylation sensitivity by rapidly removing non-toxic 7-methylguanine adducts
por: Rinne, M. L., et al.
Publicado: (2005)

Reversal of MRP7 (ABCC10)-Mediated Multidrug Resistance by Tariquidar
por: Sun, Yue-Li, et al.
Publicado: (2013)

In vivo knock-down of multidrug resistance transporters ABCC1 and ABCC2 by AAV-delivered shRNAs and by artificial miRNAs
por: Borel, Florie, et al.
Publicado: (2011)

Functional Expression of Multidrug Resistance Protein 4 MRP4/ABCC4
por: Hardy, David, et al.
Publicado: (2019)

Tandutinib (MLN518) reverses multidrug resistance by inhibiting the efflux activity of the multidrug resistance protein 7 (ABCC10)
por: DENG, WEN, et al.
Publicado: (2013)

ABCC3 as a marker for multidrug resistance in non-small cell lung cancer
por: Zhao, Yanbin, et al.
Publicado: (2013)

ABCC4 Is a Determinant of Cytarabine‐Induced Cytotoxicity and Myelosuppression
por: Drenberg, CD, et al.
Publicado: (2016)

(R)-[(11)C]verapamil is selectively transported by murine and human P-glycoprotein at the blood–brain barrier, and not by MRP1 and BCRP
por: Römermann, Kerstin, et al.
Publicado: (2013)

ABCC Multidrug Transporters in Childhood Neuroblastoma: Clinical and Biological Effects Independent of Cytotoxic Drug Efflux
por: Henderson, Michelle J., et al.
Publicado: (2011)

Identification and bioinformatic characterization of a multidrug resistance associated protein (ABCC) gene in Plasmodium berghei
por: González-Pons, María, et al.
Publicado: (2009)

Multidrug transporter MRP4/ABCC4 as a key determinant of pancreatic cancer aggressiveness
por: Sahores, A., et al.
Publicado: (2020)

Tobacco Smoke and Inhaled Drugs Alter Expression and Activity of Multidrug Resistance-Associated Protein-1 (MRP1) in Human Distal Lung Epithelial Cells in vitro
por: Selo, Mohammed Ali, et al.
Publicado: (2020)

BEZ235 impairs gastric cancer growth by inhibition of PI3K/mTOR in vitro and in vivo
por: Füreder, Thorsten, et al.
Publicado: (2010)

Virtual screening of ABCC1 transporter nucleotidebinding domains as a therapeutic target in multidrug resistant cancer
por: Rungsardthong, Kanin, et al.
Publicado: (2012)

Development of liposomal pemetrexed for enhanced therapy against multidrug resistance mediated by ABCC5 in breast cancer
por: Bai, Fang, et al.
Publicado: (2018)

Imatinib and Nilotinib Reverse Multidrug Resistance in Cancer Cells by Inhibiting the Efflux Activity of the MRP7 (ABCC10)
por: Shen, Tong, et al.
Publicado: (2009)

Stabilization of Human Multidrug Resistance Protein 4 (MRP4/ABCC4) Using Novel Solubilization Agents
por: Hardy, David, et al.
Publicado: (2019)

Molecular analysis of the massive GSH transport mechanism mediated by the human Multidrug Resistant Protein 1/ABCC1
por: Nasr, Rachad, et al.
Publicado: (2020)

Roles of ABCC1 and ABCC4 in Proliferation and Migration of Breast Cancer Cell Lines
por: Low, Floren G., et al.
Publicado: (2020)

Promoter DNA Methylation Regulates Murine SUR1 (Abcc8) and SUR2 (Abcc9) Expression in HL-1 Cardiomyocytes
por: Fatima, Naheed, et al.
Publicado: (2012)

Characterisation of the roles of ABCB1, ABCC1, ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo
por: Hill, Christopher R., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_5q68b5vh7srq5mhc2gigo7ns5p