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Choice of surgical procedure – lobectomy, segmentectomy, or wedge resection – for patients with stage T1‐2N0M0 small cell lung cancer: A population‐based study

BACKGROUND: To date, few studies have evaluated the impact of lobectomy versus sublobar resection for early small cell lung cancer (SCLC). We investigated the survival rates of patients with pathological stage T1‐2N0M0 SCLC who underwent lobectomy or sublobar resection. METHODS: We identified 548 SC...

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Autores principales: Liu, Yang, Shan, Lanlan, Shen, Jianfei, Liu, Liping, Wang, Jinlin, He, Jiaxi, He, Qihua, Jiang, Long, Guo, Minzhang, Chen, Xuewei, Zeng, Haikang, Xia, Xiaojun, Peng, Guilin, Liang, Wenhua, He, Jianxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449329/
https://www.ncbi.nlm.nih.gov/pubmed/30854808
http://dx.doi.org/10.1111/1759-7714.12943
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author Liu, Yang
Shan, Lanlan
Shen, Jianfei
Liu, Liping
Wang, Jinlin
He, Jiaxi
He, Qihua
Jiang, Long
Guo, Minzhang
Chen, Xuewei
Zeng, Haikang
Xia, Xiaojun
Peng, Guilin
Liang, Wenhua
He, Jianxing
author_facet Liu, Yang
Shan, Lanlan
Shen, Jianfei
Liu, Liping
Wang, Jinlin
He, Jiaxi
He, Qihua
Jiang, Long
Guo, Minzhang
Chen, Xuewei
Zeng, Haikang
Xia, Xiaojun
Peng, Guilin
Liang, Wenhua
He, Jianxing
author_sort Liu, Yang
collection PubMed
description BACKGROUND: To date, few studies have evaluated the impact of lobectomy versus sublobar resection for early small cell lung cancer (SCLC). We investigated the survival rates of patients with pathological stage T1‐2N0M0 SCLC who underwent lobectomy or sublobar resection. METHODS: We identified 548 SCLC patients in the Surveillance, Epidemiology, and End Results database who underwent lobectomy or sublobar resection. Propensity score matching (PSM) and Cox regression analysis were used to adjust for baseline characteristics. RESULTS: The three‐year overall survival (OS) of patients treated with lobectomy (n = 376, 60%) was significantly higher than those treated with sublobar resection (n = 172, 38%). PSM and Cox multivariable analysis further confirmed this result (hazard ratio [HR] 0.543, 95% confidence interval [CI] 0.421–0.680; P < 0.001). The three‐year OS of patients treated with segmentectomy (n = 24, 54%) and wedge resection (n = 148, 36%) was not significantly different (HR 0.639, 95% CI 0.393–1.039; P = 0.071). Based on PSM analysis, segmentectomy conferred a superior survival advantage to patients relative to wedge resection (HR 0.466, 95% CI 0.221–0.979; P = 0.040). CONCLUSION: Lobectomy correlated with superior survival. For patients in which lobectomy is unsuitable, prognosis following segmentectomy appears to be better than after wedge resection.
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spelling pubmed-64493292019-04-15 Choice of surgical procedure – lobectomy, segmentectomy, or wedge resection – for patients with stage T1‐2N0M0 small cell lung cancer: A population‐based study Liu, Yang Shan, Lanlan Shen, Jianfei Liu, Liping Wang, Jinlin He, Jiaxi He, Qihua Jiang, Long Guo, Minzhang Chen, Xuewei Zeng, Haikang Xia, Xiaojun Peng, Guilin Liang, Wenhua He, Jianxing Thorac Cancer Original Articles BACKGROUND: To date, few studies have evaluated the impact of lobectomy versus sublobar resection for early small cell lung cancer (SCLC). We investigated the survival rates of patients with pathological stage T1‐2N0M0 SCLC who underwent lobectomy or sublobar resection. METHODS: We identified 548 SCLC patients in the Surveillance, Epidemiology, and End Results database who underwent lobectomy or sublobar resection. Propensity score matching (PSM) and Cox regression analysis were used to adjust for baseline characteristics. RESULTS: The three‐year overall survival (OS) of patients treated with lobectomy (n = 376, 60%) was significantly higher than those treated with sublobar resection (n = 172, 38%). PSM and Cox multivariable analysis further confirmed this result (hazard ratio [HR] 0.543, 95% confidence interval [CI] 0.421–0.680; P < 0.001). The three‐year OS of patients treated with segmentectomy (n = 24, 54%) and wedge resection (n = 148, 36%) was not significantly different (HR 0.639, 95% CI 0.393–1.039; P = 0.071). Based on PSM analysis, segmentectomy conferred a superior survival advantage to patients relative to wedge resection (HR 0.466, 95% CI 0.221–0.979; P = 0.040). CONCLUSION: Lobectomy correlated with superior survival. For patients in which lobectomy is unsuitable, prognosis following segmentectomy appears to be better than after wedge resection. John Wiley & Sons Australia, Ltd 2019-03-10 2019-04 /pmc/articles/PMC6449329/ /pubmed/30854808 http://dx.doi.org/10.1111/1759-7714.12943 Text en © 2018 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Liu, Yang
Shan, Lanlan
Shen, Jianfei
Liu, Liping
Wang, Jinlin
He, Jiaxi
He, Qihua
Jiang, Long
Guo, Minzhang
Chen, Xuewei
Zeng, Haikang
Xia, Xiaojun
Peng, Guilin
Liang, Wenhua
He, Jianxing
Choice of surgical procedure – lobectomy, segmentectomy, or wedge resection – for patients with stage T1‐2N0M0 small cell lung cancer: A population‐based study
title Choice of surgical procedure – lobectomy, segmentectomy, or wedge resection – for patients with stage T1‐2N0M0 small cell lung cancer: A population‐based study
title_full Choice of surgical procedure – lobectomy, segmentectomy, or wedge resection – for patients with stage T1‐2N0M0 small cell lung cancer: A population‐based study
title_fullStr Choice of surgical procedure – lobectomy, segmentectomy, or wedge resection – for patients with stage T1‐2N0M0 small cell lung cancer: A population‐based study
title_full_unstemmed Choice of surgical procedure – lobectomy, segmentectomy, or wedge resection – for patients with stage T1‐2N0M0 small cell lung cancer: A population‐based study
title_short Choice of surgical procedure – lobectomy, segmentectomy, or wedge resection – for patients with stage T1‐2N0M0 small cell lung cancer: A population‐based study
title_sort choice of surgical procedure – lobectomy, segmentectomy, or wedge resection – for patients with stage t1‐2n0m0 small cell lung cancer: a population‐based study
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449329/
https://www.ncbi.nlm.nih.gov/pubmed/30854808
http://dx.doi.org/10.1111/1759-7714.12943
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