A bacterial checkpoint protein for ribosome assembly moonlights as an essential metabolite-proofreading enzyme

In eukaryotes, adventitious oxidation of erythrose-4-phosphate, an intermediate of the pentose phosphate pathway (PPP), generates 4-phosphoerythronate (4PE), which inhibits 6-phosphogluconate dehydrogenase. 4PE is detoxified by metabolite-proofreading phosphatases such as yeast Pho13. Here, we repor...

Descripción completa

Detalles Bibliográficos
Autores principales: Sachla, Ankita J., Helmann, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449344/
https://www.ncbi.nlm.nih.gov/pubmed/30948730
http://dx.doi.org/10.1038/s41467-019-09508-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449344/
https://www.ncbi.nlm.nih.gov/pubmed/30948730
http://dx.doi.org/10.1038/s41467-019-09508-z

Ejemplares similares