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A bacterial checkpoint protein for ribosome assembly moonlights as an essential metabolite-proofreading enzyme
In eukaryotes, adventitious oxidation of erythrose-4-phosphate, an intermediate of the pentose phosphate pathway (PPP), generates 4-phosphoerythronate (4PE), which inhibits 6-phosphogluconate dehydrogenase. 4PE is detoxified by metabolite-proofreading phosphatases such as yeast Pho13. Here, we repor...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449344/ https://www.ncbi.nlm.nih.gov/pubmed/30948730 http://dx.doi.org/10.1038/s41467-019-09508-z |