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Area-dependent change of response in the rat’s inferior colliculus to intracochlear electrical stimulation following neonatal cochlear damage

To understand brain changes caused by auditory sensory deprivation, we recorded local-field potentials in the inferior colliculus of young adult rats with neonatal cochlear damage produced by systemic injections of amikacin. The responses were elicited by electrical stimulation of the entire cochlea...

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Autores principales: Hatano, Miyako, Kelly, Jack B., Zhang, Huiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449351/
https://www.ncbi.nlm.nih.gov/pubmed/30948747
http://dx.doi.org/10.1038/s41598-019-41955-y
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author Hatano, Miyako
Kelly, Jack B.
Zhang, Huiming
author_facet Hatano, Miyako
Kelly, Jack B.
Zhang, Huiming
author_sort Hatano, Miyako
collection PubMed
description To understand brain changes caused by auditory sensory deprivation, we recorded local-field potentials in the inferior colliculus of young adult rats with neonatal cochlear damage produced by systemic injections of amikacin. The responses were elicited by electrical stimulation of the entire cochlea and recorded at various locations along a dorsolateral-ventromedial axis of the inferior colliculus. We found that hair cells were completely destroyed and spiral ganglion neurons were severely damaged in the basal cochleae of amikacin-treated animals. Hair cells as well as spiral ganglion neurons were damaged also in the middle and apical areas of the cochlea, with the damage being greater in the middle than the apical area. Amplitudes of local-field potentials were reduced in the ventromedial inferior colliculus, but enhanced in the dorsolateral inferior colliculus. Latencies of responses were increased over the entire structure. The enhancement of responses in the dorsolateral inferior colliculus was in contrast with the damage of hair cells and spiral ganglion cells in the apical part of the cochlea. This contrast along with the overall increase of latencies suggests that early cochlear damage can alter neural mechanisms within the inferior colliculus and/or the inputs to this midbrain structure.
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spelling pubmed-64493512019-04-10 Area-dependent change of response in the rat’s inferior colliculus to intracochlear electrical stimulation following neonatal cochlear damage Hatano, Miyako Kelly, Jack B. Zhang, Huiming Sci Rep Article To understand brain changes caused by auditory sensory deprivation, we recorded local-field potentials in the inferior colliculus of young adult rats with neonatal cochlear damage produced by systemic injections of amikacin. The responses were elicited by electrical stimulation of the entire cochlea and recorded at various locations along a dorsolateral-ventromedial axis of the inferior colliculus. We found that hair cells were completely destroyed and spiral ganglion neurons were severely damaged in the basal cochleae of amikacin-treated animals. Hair cells as well as spiral ganglion neurons were damaged also in the middle and apical areas of the cochlea, with the damage being greater in the middle than the apical area. Amplitudes of local-field potentials were reduced in the ventromedial inferior colliculus, but enhanced in the dorsolateral inferior colliculus. Latencies of responses were increased over the entire structure. The enhancement of responses in the dorsolateral inferior colliculus was in contrast with the damage of hair cells and spiral ganglion cells in the apical part of the cochlea. This contrast along with the overall increase of latencies suggests that early cochlear damage can alter neural mechanisms within the inferior colliculus and/or the inputs to this midbrain structure. Nature Publishing Group UK 2019-04-04 /pmc/articles/PMC6449351/ /pubmed/30948747 http://dx.doi.org/10.1038/s41598-019-41955-y Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Hatano, Miyako
Kelly, Jack B.
Zhang, Huiming
Area-dependent change of response in the rat’s inferior colliculus to intracochlear electrical stimulation following neonatal cochlear damage
title Area-dependent change of response in the rat’s inferior colliculus to intracochlear electrical stimulation following neonatal cochlear damage
title_full Area-dependent change of response in the rat’s inferior colliculus to intracochlear electrical stimulation following neonatal cochlear damage
title_fullStr Area-dependent change of response in the rat’s inferior colliculus to intracochlear electrical stimulation following neonatal cochlear damage
title_full_unstemmed Area-dependent change of response in the rat’s inferior colliculus to intracochlear electrical stimulation following neonatal cochlear damage
title_short Area-dependent change of response in the rat’s inferior colliculus to intracochlear electrical stimulation following neonatal cochlear damage
title_sort area-dependent change of response in the rat’s inferior colliculus to intracochlear electrical stimulation following neonatal cochlear damage
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449351/
https://www.ncbi.nlm.nih.gov/pubmed/30948747
http://dx.doi.org/10.1038/s41598-019-41955-y
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