Reducing Mcl-1 gene dosage induces dopaminergic neuronal loss and motor impairments in Park2 knockout mice

Mutations in the PARK2 gene are associated with early onset Parkinsonism. The Park2(−/−) mouse, however, does not exhibit neurodegeneration or other Parkinson’s disease (PD) phenotypes. Previously, we discovered that translation of Mcl-1, a pro-survival factor, is upregulated in the Park2(−/−) mouse...

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Detalles Bibliográficos
Autores principales: Ekholm-Reed, Susanna, Baker, Robert, Campos, Alexandre R., Stouffer, David, Henze, Martha, Wolf, Dieter A., Loring, Jeanne F., Thomas, Elizabeth A., Reed, Steven I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449387/
https://www.ncbi.nlm.nih.gov/pubmed/30963113
http://dx.doi.org/10.1038/s42003-019-0366-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449387/
https://www.ncbi.nlm.nih.gov/pubmed/30963113
http://dx.doi.org/10.1038/s42003-019-0366-x

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