Cargando…

Glucose-dependent Insulinotropic Polypeptide (GIP) Resistance and β-cell Dysfunction Contribute to Hyperglycaemia in Acromegaly

Impaired insulin sensitivity (IS) and β-cell dysfunction result in hyperglycaemia in patients of acromegaly. However, alterations in incretins and their impact on glucose-insulin homeostasis in these patients still remain elusive. Twenty patients of active acromegaly (10 each, with and without diabe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shekhawat, Vikram Singh, Bhansali, Shobhit, Dutta, Pinaki, Mukherjee, Kanchan Kumar, Vaiphei, Kim, Kochhar, Rakesh, Sinha, Saroj K., Sachdeva, Naresh, Kurpad, Anura V., Bhat, Kishor, Mudaliar, Sunder, Bhansali, Anil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449401/ https://www.ncbi.nlm.nih.gov/pubmed/30948746 http://dx.doi.org/10.1038/s41598-019-41887-7

Ejemplares similares

Effect of Linagliptin and Voglibose on metabolic profile in patients with Type 2 Diabetes: a randomized, double-blind, placebo-controlled trial
por: Parthan, Girish, et al.
Publicado: (2018)

Autologous bone marrow-derived mononuclear cells transplantation in type 2 diabetes mellitus: effect on β-cell function and insulin sensitivity
por: Bhansali, Shobhit, et al.
Publicado: (2017)

Glucose-dependent insulinotropic polypeptide (GIP) and GIP receptor (GIPR) genes: An association analysis of polymorphisms and bone in young and elderly women
por: Garg, Gaurav, et al.
Publicado: (2015)

Glucose-Dependent Insulinotropic Polypeptide (GIP) Reduces Bone Resorption in Patients With Type 2 Diabetes
por: Christensen, Mikkel B, et al.
Publicado: (2020)

Short-term efficacy of recombinant human GH therapy in cured acromegaly patients with GH deficiency: a single-center experience
por: Dutta, Pinaki, et al.
Publicado: (2015)

Investigation of endothelial nitric oxide (NO) signalling in response to the incretin hormone glucose-dependent insulinotropic polypeptide (GIP)
por: Savage, PJ, et al.
Publicado: (2012)

The effect of glucose-dependent insulinotropic polypeptide (GIP) variants on visceral fat accumulation in Han Chinese populations
por: Wang, T, et al.
Publicado: (2017)

The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling
por: Zhang, Qian, et al.
Publicado: (2021)

Administration of Jerusalem artichoke reduces the postprandial plasma glucose and glucose-dependent insulinotropic polypeptide (GIP) concentrations in humans
por: Takahashi, Hirokazu, et al.
Publicado: (2022)

Over-expression, purification and isotopic labeling of a tag-less human glucose-dependent insulinotropic polypeptide (hGIP)
por: Chandarana, Rakesh C., et al.
Publicado: (2013)

Sitagliptin decreases ventricular arrhythmias by attenuated glucose-dependent insulinotropic polypeptide (GIP)-dependent resistin signalling in infarcted rats
por: Lee, Tsung-Ming, et al.
Publicado: (2016)

Nephroprotective Properties of the Glucose-Dependent Insulinotropic Polypeptide (GIP) and Glucagon-like Peptide-1 (GLP-1) Receptor Agonists
por: Bulum, Tomislav
Publicado: (2022)

Effect of a Dual PPAR α/γ agonist on Insulin Sensitivity in Patients of Type 2 Diabetes with Hypertriglyceridemia- Randomized double-blind placebo-controlled trial
por: Jain, Nimisha, et al.
Publicado: (2019)

Attenuated secretion of glucose-dependent insulinotropic polypeptide (GIP) does not alleviate hyperphagic obesity and insulin resistance in ob/ob mice
por: Shimazu-Kuwahara, Satoko, et al.
Publicado: (2017)

GIP_HUMAN [22–51] Peptide Encoded by the Glucose-Dependent Insulinotropic Polypeptide (GIP) Gene Suppresses Insulin Expression and Secretion in INS-1E Cells and Rat Pancreatic Islets
por: Pusch, Emily, et al.
Publicado: (2023)

N‐terminally and C‐terminally truncated forms of glucose‐dependent insulinotropic polypeptide are high‐affinity competitive antagonists of the human GIP receptor
por: Hansen, L S, et al.
Publicado: (2016)

Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the GIPR Region
por: Bowker, Nicholas, et al.
Publicado: (2021)

Lixisenatide reduces postprandial hyperglycaemia via gastrostatic and insulinotropic effects
por: Becker, Reinhard H. A., et al.
Publicado: (2015)

Localized acromegaly
por: Palikhe, Gaurav, et al.
Publicado: (2012)

Physiologic and Pharmacologic Modulation of Glucose-Dependent Insulinotropic Polypeptide (GIP) Receptor Expression in β-Cells by Peroxisome Proliferator–Activated Receptor (PPAR)-γ Signaling: Possible Mechanism for the GIP Resistance in Type 2 Diabetes
por: Gupta, Dhananjay, et al.
Publicado: (2010)

Congestive heart failure in acromegaly: A review of 6 cases
por: Dutta, P., et al.
Publicado: (2012)

The dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist tirzepatide: a novel cardiometabolic therapeutic prospect
por: Fisman, Enrique Z., et al.
Publicado: (2021)

Imaging of the Glucose-Dependent Insulinotropic Polypeptide Receptor Using a Novel Radiolabeled Peptide Rationally Designed Based on Endogenous GIP and Synthetic Exendin-4 Sequences
por: Velikyan, Irina, et al.
Publicado: (2022)

Validation of bedside methods in evaluation of diabetic peripheral neuropathy
por: Jayaprakash, P., et al.
Publicado: (2011)

Does Primary BCG Vaccination Prevent Autoimmune Hypothyroid Disease?
por: Agrawal, Kanhaiya, et al.
Publicado: (2021)

Gastric inhibitory polypeptide/glucose‐dependent insulinotropic polypeptide signaling in adipose tissue
por: Yamane, Shunsuke, et al.
Publicado: (2018)

Ethnic disparities in insulin and glucose-dependent insulinotropic peptide (GIP) responses to intraduodenal glucose in health
por: Marathe, Chinmay S., et al.
Publicado: (2014)

Searching for the physiological role of glucose‐dependent insulinotropic polypeptide
por: Holst, Jens Juul, et al.
Publicado: (2016)

Serum Glucose-Dependent Insulinotropic Polypeptide (GIP) and Glucagon-Like Peptide-1 (GLP-1) in association with the Risk of Gestational Diabetes: A Prospective Case-Control Study
por: Mosavat, Maryam, et al.
Publicado: (2020)

Effect of mesenchymal stem cells transplantation on glycaemic profile & their localization in streptozotocin induced diabetic Wistar rats
por: Bhansali, Shobhit, et al.
Publicado: (2015)

Authors’ response
por: Bhansali, Shobhit, et al.
Publicado: (2016)

Effect of zoledronic acid on bone mineral density in patients of celiac disease: A prospective, randomized, pilot study
por: Kumar, Mukul, et al.
Publicado: (2013)

Anti‐inflammatory role of glucose‐dependent insulinotropic polypeptide in periodontitis
por: Suzuki, Yuki, et al.
Publicado: (2016)

Roles of glucose‐dependent insulinotropic polypeptide in diet‐induced obesity
por: Seino, Yusuke, et al.
Publicado: (2022)

Spontaneous diabetic myonecrosis: report of four cases from a tertiary care institute
por: Mukherjee, Soham, et al.
Publicado: (2015)

The Expression and Function of Glucose-Dependent Insulinotropic Polypeptide in the Embryonic Mouse Pancreas
por: Prasadan, Krishna, et al.
Publicado: (2011)

Glucose‐dependent insulinotropic polypeptide signaling in pancreatic β‐cells and adipocytes
por: McIntosh, Christopher HS, et al.
Publicado: (2012)

Gastrointestinal Incretins—Glucose-Dependent Insulinotropic Polypeptide (GIP) and Glucagon-like Peptide-1 (GLP-1) beyond Pleiotropic Physiological Effects Are Involved in Pathophysiology of Atherosclerosis and Coronary Artery Disease—State of the Art
por: Jonik, Szymon, et al.
Publicado: (2022)

Mechanisms of fat‐induced gastric inhibitory polypeptide/glucose‐dependent insulinotropic polypeptide secretion from K cells
por: Yamane, Shunsuke, et al.
Publicado: (2016)

Authors’ response
por: Walia, Rama, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_u8rai16ff2laoue9o64ek7jvlf