Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory

Functional changes in spatial genome organization during human development are poorly understood. Here we report a comprehensive profile of nuclear dynamics during human cardiogenesis from pluripotent stem cells by integrating Hi-C, RNA-seq and ATAC-seq. While chromatin accessibility and gene expres...

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Detalles Bibliográficos
Autores principales: Bertero, Alessandro, Fields, Paul A., Ramani, Vijay, Bonora, Giancarlo, Yardimci, Galip G., Reinecke, Hans, Pabon, Lil, Noble, William S., Shendure, Jay, Murry, Charles E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449405/
https://www.ncbi.nlm.nih.gov/pubmed/30948719
http://dx.doi.org/10.1038/s41467-019-09483-5

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