Cargando…
OSlms: A Web Server to Evaluate the Prognostic Value of Genes in Leiomyosarcoma
The availability of transcriptome data and clinical annotation offers the opportunity to identify prognosis biomarkers in cancer. However, efficient online prognosis analysis tools are still lacking. Herein, we developed a user-friendly web server, namely Online consensus Survival analysis of leiomy...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449415/ https://www.ncbi.nlm.nih.gov/pubmed/30984618 http://dx.doi.org/10.3389/fonc.2019.00190 |
_version_ | 1783408840713175040 |
---|---|
author | Wang, Qiang Xie, Longxiang Dang, Yifang Sun, Xiaoxiao Xie, Tiantian Guo, Jinshuai Han, Yali Yan, Zhongyi Zhu, Wan Wang, Yunlong Li, Wei Guo, Xiangqian |
author_facet | Wang, Qiang Xie, Longxiang Dang, Yifang Sun, Xiaoxiao Xie, Tiantian Guo, Jinshuai Han, Yali Yan, Zhongyi Zhu, Wan Wang, Yunlong Li, Wei Guo, Xiangqian |
author_sort | Wang, Qiang |
collection | PubMed |
description | The availability of transcriptome data and clinical annotation offers the opportunity to identify prognosis biomarkers in cancer. However, efficient online prognosis analysis tools are still lacking. Herein, we developed a user-friendly web server, namely Online consensus Survival analysis of leiomyosarcoma (OSlms), to centralize published gene expression data and clinical datasets of leiomyosarcoma (LMS) patients from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). OSlms comprises of a total of 268 samples from three independent datasets, and employs the Kaplan Meier survival plot with hazard ratio (HR) and log rank test to estimate the prognostic potency of genes of interests for LMS patients. Using OSlms, clinicians and basic researchers could determine the prognostic significance of genes of interests and get opportunities to identify novel potential important molecules for LMS. OSlms is free and publicly accessible at http://bioinfo.henu.edu.cn/LMS/LMSList.jsp. |
format | Online Article Text |
id | pubmed-6449415 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64494152019-04-12 OSlms: A Web Server to Evaluate the Prognostic Value of Genes in Leiomyosarcoma Wang, Qiang Xie, Longxiang Dang, Yifang Sun, Xiaoxiao Xie, Tiantian Guo, Jinshuai Han, Yali Yan, Zhongyi Zhu, Wan Wang, Yunlong Li, Wei Guo, Xiangqian Front Oncol Oncology The availability of transcriptome data and clinical annotation offers the opportunity to identify prognosis biomarkers in cancer. However, efficient online prognosis analysis tools are still lacking. Herein, we developed a user-friendly web server, namely Online consensus Survival analysis of leiomyosarcoma (OSlms), to centralize published gene expression data and clinical datasets of leiomyosarcoma (LMS) patients from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). OSlms comprises of a total of 268 samples from three independent datasets, and employs the Kaplan Meier survival plot with hazard ratio (HR) and log rank test to estimate the prognostic potency of genes of interests for LMS patients. Using OSlms, clinicians and basic researchers could determine the prognostic significance of genes of interests and get opportunities to identify novel potential important molecules for LMS. OSlms is free and publicly accessible at http://bioinfo.henu.edu.cn/LMS/LMSList.jsp. Frontiers Media S.A. 2019-03-29 /pmc/articles/PMC6449415/ /pubmed/30984618 http://dx.doi.org/10.3389/fonc.2019.00190 Text en Copyright © 2019 Wang, Xie, Dang, Sun, Xie, Guo, Han, Yan, Zhu, Wang, Li and Guo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Wang, Qiang Xie, Longxiang Dang, Yifang Sun, Xiaoxiao Xie, Tiantian Guo, Jinshuai Han, Yali Yan, Zhongyi Zhu, Wan Wang, Yunlong Li, Wei Guo, Xiangqian OSlms: A Web Server to Evaluate the Prognostic Value of Genes in Leiomyosarcoma |
title | OSlms: A Web Server to Evaluate the Prognostic Value of Genes in Leiomyosarcoma |
title_full | OSlms: A Web Server to Evaluate the Prognostic Value of Genes in Leiomyosarcoma |
title_fullStr | OSlms: A Web Server to Evaluate the Prognostic Value of Genes in Leiomyosarcoma |
title_full_unstemmed | OSlms: A Web Server to Evaluate the Prognostic Value of Genes in Leiomyosarcoma |
title_short | OSlms: A Web Server to Evaluate the Prognostic Value of Genes in Leiomyosarcoma |
title_sort | oslms: a web server to evaluate the prognostic value of genes in leiomyosarcoma |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449415/ https://www.ncbi.nlm.nih.gov/pubmed/30984618 http://dx.doi.org/10.3389/fonc.2019.00190 |
work_keys_str_mv | AT wangqiang oslmsawebservertoevaluatetheprognosticvalueofgenesinleiomyosarcoma AT xielongxiang oslmsawebservertoevaluatetheprognosticvalueofgenesinleiomyosarcoma AT dangyifang oslmsawebservertoevaluatetheprognosticvalueofgenesinleiomyosarcoma AT sunxiaoxiao oslmsawebservertoevaluatetheprognosticvalueofgenesinleiomyosarcoma AT xietiantian oslmsawebservertoevaluatetheprognosticvalueofgenesinleiomyosarcoma AT guojinshuai oslmsawebservertoevaluatetheprognosticvalueofgenesinleiomyosarcoma AT hanyali oslmsawebservertoevaluatetheprognosticvalueofgenesinleiomyosarcoma AT yanzhongyi oslmsawebservertoevaluatetheprognosticvalueofgenesinleiomyosarcoma AT zhuwan oslmsawebservertoevaluatetheprognosticvalueofgenesinleiomyosarcoma AT wangyunlong oslmsawebservertoevaluatetheprognosticvalueofgenesinleiomyosarcoma AT liwei oslmsawebservertoevaluatetheprognosticvalueofgenesinleiomyosarcoma AT guoxiangqian oslmsawebservertoevaluatetheprognosticvalueofgenesinleiomyosarcoma |