Identification of a Functional Non-coding Variant in the GABA(A) Receptor α2 Subunit of the C57BL/6J Mouse Reference Genome: Major Implications for Neuroscience Research

GABA type-A (GABA-A) receptors containing the α2 subunit (GABRA2) are expressed in most brain regions and are critical in modulating inhibitory synaptic function. Genetic variation at the GABRA2 locus has been implicated in epilepsy, affective and psychiatric disorders, alcoholism and drug abuse. Ga...

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Detalles Bibliográficos
Autores principales: Mulligan, Megan K., Abreo, Timothy, Neuner, Sarah M., Parks, Cory, Watkins, Christine E., Houseal, M. Trevor, Shapaker, Thomas M., Hook, Michael, Tan, Haiyan, Wang, Xusheng, Ingels, Jesse, Peng, Junmin, Lu, Lu, Kaczorowski, Catherine C., Bryant, Camron D., Homanics, Gregg E., Williams, Robert W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449455/
https://www.ncbi.nlm.nih.gov/pubmed/30984232
http://dx.doi.org/10.3389/fgene.2019.00188

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