The Role of PGC-1α/UCP2 Signaling in the Beneficial Effects of Physical Exercise on the Brain

In understanding the pathology of neurological diseases, the role played by brain energy metabolism is gaining prominence. Animal models have demonstrated that regular physical exercise improves brain energy metabolism while also providing antidepressant, anxiolytic, antioxidant and neuroprotective...

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Detalles Bibliográficos
Autores principales: de Oliveira Bristot, Viviane José, de Bem Alves, Ana Cristina, Cardoso, Liziane Rosa, da Luz Scheffer, Débora, Aguiar, Aderbal Silva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449457/
https://www.ncbi.nlm.nih.gov/pubmed/30983964
http://dx.doi.org/10.3389/fnins.2019.00292
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author de Oliveira Bristot, Viviane José
de Bem Alves, Ana Cristina
Cardoso, Liziane Rosa
da Luz Scheffer, Débora
Aguiar, Aderbal Silva
author_facet de Oliveira Bristot, Viviane José
de Bem Alves, Ana Cristina
Cardoso, Liziane Rosa
da Luz Scheffer, Débora
Aguiar, Aderbal Silva
author_sort de Oliveira Bristot, Viviane José
collection PubMed
description In understanding the pathology of neurological diseases, the role played by brain energy metabolism is gaining prominence. Animal models have demonstrated that regular physical exercise improves brain energy metabolism while also providing antidepressant, anxiolytic, antioxidant and neuroprotective functions. This review summarizes the latest evidence on the roles played by peroxisome proliferator-activated receptor gamma (PPAR-γ) coactivator 1-alpha (PGC-1α) and mitochondrial uncoupling protein (UCP) in this scenario. The beneficial effects of exercise seem to depend on crosstalk between muscles and nervous tissue through the increased release of muscle irisin during exercise.
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spelling pubmed-64494572019-04-12 The Role of PGC-1α/UCP2 Signaling in the Beneficial Effects of Physical Exercise on the Brain de Oliveira Bristot, Viviane José de Bem Alves, Ana Cristina Cardoso, Liziane Rosa da Luz Scheffer, Débora Aguiar, Aderbal Silva Front Neurosci Neuroscience In understanding the pathology of neurological diseases, the role played by brain energy metabolism is gaining prominence. Animal models have demonstrated that regular physical exercise improves brain energy metabolism while also providing antidepressant, anxiolytic, antioxidant and neuroprotective functions. This review summarizes the latest evidence on the roles played by peroxisome proliferator-activated receptor gamma (PPAR-γ) coactivator 1-alpha (PGC-1α) and mitochondrial uncoupling protein (UCP) in this scenario. The beneficial effects of exercise seem to depend on crosstalk between muscles and nervous tissue through the increased release of muscle irisin during exercise. Frontiers Media S.A. 2019-03-29 /pmc/articles/PMC6449457/ /pubmed/30983964 http://dx.doi.org/10.3389/fnins.2019.00292 Text en Copyright © 2019 de Oliveira Bristot, de Bem Alves, Cardoso, da Luz Scheffer and Aguiar. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
de Oliveira Bristot, Viviane José
de Bem Alves, Ana Cristina
Cardoso, Liziane Rosa
da Luz Scheffer, Débora
Aguiar, Aderbal Silva
The Role of PGC-1α/UCP2 Signaling in the Beneficial Effects of Physical Exercise on the Brain
title The Role of PGC-1α/UCP2 Signaling in the Beneficial Effects of Physical Exercise on the Brain
title_full The Role of PGC-1α/UCP2 Signaling in the Beneficial Effects of Physical Exercise on the Brain
title_fullStr The Role of PGC-1α/UCP2 Signaling in the Beneficial Effects of Physical Exercise on the Brain
title_full_unstemmed The Role of PGC-1α/UCP2 Signaling in the Beneficial Effects of Physical Exercise on the Brain
title_short The Role of PGC-1α/UCP2 Signaling in the Beneficial Effects of Physical Exercise on the Brain
title_sort role of pgc-1α/ucp2 signaling in the beneficial effects of physical exercise on the brain
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449457/
https://www.ncbi.nlm.nih.gov/pubmed/30983964
http://dx.doi.org/10.3389/fnins.2019.00292
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